Words similar to epididymis
Example sentences for: epididymis
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Apoptotic cells were identified by the TdT-mediated dUTP-biotin nick end labeling (TUNEL) method and detected either by flow cytometry [ 27 ] or by light microscopy in histological sections [ 28 ] . The results indicate that transgenic ABP alters the rate of testicular germ cell apoptosis throughout life, but it is most likely to cause its germ-cell depleting effect by promoting germ cell apoptosis during the critical pre-pubertal period ("puberty" in laboratory rodents occurs at 50-60 days of life and is defined as the first appearance of spermatozoa in the tail of the epididymis [ 29 30 ] ).
For this reason, it was thought worthwhile to investigate the presence of SPAM1 in the human epididymis and vas deferens for which a possible role in sperm maturation has been proposed [ 14 ] . Because of the difficulty in obtaining fresh human tissue we included in our study tissues of cynomolgus macaque which is a primate model for studying human sperm maturation [ 15 ] .
It should also be noted that a study of the glycosylation and 2D-gel patterns of Spam1 from the epididymis and testis of mice indicates that epididymal Spam1 may be a unique isoform rather than a redundant protein [ 33 ] . Such a unique isoform may play a specific role in sperm maturation in humans where SPAM1 is the only reproductive hyaluronidase in the cluster on 7q31.
Tissues from Subject #3 and 4, who were 27 and 68 years old, were obtained in the form of slides made from paraffin-embedded sections of testis, epididymis, vas deferens, and seminal vesicles through Novagen (Madison, WI).
Variations in glycosylation patterns have been shown to exist among tissues [ 31 ] and glycosylation levels have been reported to influence hyaluronidase activity of SPAM1 in the mouse and horse [ 10 32 ] . Note that in the mouse, tissue differences in glycosylation patterns have been reported for the testis and epididymis [ 33 ] . It is possible that in the epididymis and vas deferens instead of hyaluronidase activity, a more important role of SPAM1 (which is a glycosidase) may be to modify surface proteins of sperm during their maturation.
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