Words similar to endonucleases
Example sentences for: endonucleases
How can you use “endonucleases” in a sentence? Here are some example sentences to help you improve your vocabulary:
We have chosen to illustrate this approach using the multifunctional family of DNA repair proteins, the apurinic/apyrimidinic endonucleases (APEs), which have a clearly defined bacterial ancestor, E. coli exonuclease III (ExoIII), and are distantly related to several enzymes with varying substrate specificity.
This alignment could be extended to the enzymatic core of three characteristic Mg 2+-dependent endonucleases: the bovine DNAseI [ 29 ] and two apurinic/apyrimidinic (AP) DNA-repair endonucleases, i.e. the E. coli Exonuclease III [ 30 ] and the human HAP1 protein [ 31 ] . These nucleases share the same catalytic residues and form a similar four-layered α/β-sandwich motif.
Both methods allow similarly large numbers of mutational variants to be simultaneously compared and competed, and both methods can potentially be adapted to a range of molecular biology enzymes that act on their own templates, such as restriction endonucleases or DNA ligases.
Like the KilA-N domains that are mainly associated with DNA viruses, the LAGLIDADG endonucleases are predominantly encoded by mobile genetic elements [ 31].
We noticed, however, that, although the TEN domain is related to the LAGLIDADG endonucleases, the active-site residues are not preserved in the former, and the TEN domain probably functions as a RNA-binding domain rather than a nuclease.