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Example sentences for: encodes
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In yeast, profilin null mutations result in cells that are viable at permissive temperature, but grow more slowly, are larger than wild type, and are often multinucleate [ 38 ] . The chickadee ( chic ) gene encodes Drosophila profilin and chic mutations produce sterile female flies [ 39 40 ] . In both species, profilin mutations resulted in defects in actin polymerization [ 38 39 40 ] . In addition to regulating actin assembly, a large body of in vitro and in vivo evidence suggests a role for profilin in signal transduction, mainly involving PIP2, a major second messenger that strongly binds to profilin [ 41 ] and localizes to the membrane microdomains described earlier.
The Ad5 Adapt mhAB encodes for a murinised form of the human ATF-BPTI (mhAB) [ 18 ] . In this construct the mhATF-BPTI, is preceded by the native secretion signal peptide of the human urokinase.
The final clone isolated in our search encodes a 433 amino acid protein whose sequence was highly conserved from human to pufferfish.
Both regions contained multiple open reading frames; however, we focused immediately on a single gene for each mutant, SEC13 for npa2-1 and SEC23 for npa1-1 . SEC13 was first identified in a screen for secretory mutants and encodes a protein of the COPII coat, which is required for vesicle budding from the ER [ 37 38 39 ] . More recently, it has been shown that a fraction of the total cellular Sec13p co-fractionates with NPCs in a distinct subcomplex with Nup84p, Nup85p, Nup120p, Nup145Cp and Seh1p [ 40 41 ] . SEC23 was also identified in a screen for secretory mutants, and it, too, is a component of the COPII coat [ 37 38 39 ] . Co-purification of Sec23p with intact NPCs has not been reported [ 5 ] ; however, Sec23p was recently isolated in Nup42p and Nup116p affinity chromatography strategies [ 42 ] . Expression constructs containing only SEC13 or SEC23 were transformed into the mutant strains and assayed for their ability to rescue growth at the non-permissive temperature.
This clone encodes an ORF of 67 amino acids whose mRNA was specifically detected in hamster testis RNA (figure 1).
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