Words similar to emmprin
Example sentences for: emmprin
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From CD98 immunoprecipitates we recovered α3β1 integrin, but not other cell surface molecules, including the LDL receptor, HLA class I, the metalloprotease regulator EMMPRIN (CD 147), CD71, or CD 109 (Fig.
2Aand 2Bindicate that CD98-integrin complexes are distinct from previously described integrin-CD81 [ 32 40 ] and integrin-CD147/EMMPRIN [ 31 ] complexes.
We utilized a monoclonal antibody screening method involving co-immunoprecipitation of integrins under non-stringent detergent conditions [ 30 31 ] . Using this approach, we have previously discovered specific associations between particular β1 integrins and other cell surface molecules including CD147/EMMPRIN [ 31 ] , and various tetraspanin (transmembrane-4 superfamily) proteins [ 30 32 33 ] . In this report we demonstrate for the first time that CD98 constitutively and specifically associates with intact β1 integrin heterodimers.
Monoclonal antibodies used in this study are: 4F2, anti-CD98 heavy chain [ 39 ] , A2-2E10, anti-α2 integrin [ 32 ] ; A3-IIF5, anti-α3 integrin [ 50 ] ; A5-PUJ2, anti-α5 integrin [ 51 ] ; B5G10, anti-α4 integrin [ 52 ] ; A4-PUJ1, anti-α4 integrin [ 51 ] ; A6-BB, anti-α6 integrin [ 32 ] ; TS2/16, anti-β1 integrin; W6/32, anti-HLA class I [ 53 ] ; C7, anti-LDL receptor [ 54 ] ; 5E9, anti-CD71 [ 55 ] ; IIIC4, anti-CD 109 [ 32 ] ; 8G6, anti-CD147/EMMPRIN [ 31 ] ; and KMI6, anti-mouse β1 integrin (Pharmingen, San Diego, CA).
Similarly, GPI-linked proteins such as CD 109, TM4SF proteins such as CD81, and other transmembrane proteins such as CD147/EMMPRIN can be found at substantial levels in light membrane fractions [ 44 45 ] , and our unpublished results), and these also did not co-immunoprecipitate with CD98 (Fig.
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