Words similar to emm

Example sentences for: emm

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Depending on the haplotypic structure of a gene region, one may be able to choose a small subset of SNPs that capture most of the haplotypic diversity, thus reducing the cost of genotyping significantly with only modest reductions in information [ 20 21 22 ] . Two methods have been reported that select the best subset of SNPs [ 20 23 ] . In this paper we introduce a third, the entropy maximization method (EMM), which chooses the subset of SNPs that explains the largest proportion of the underlying haplotypic diversity as measured by entropy.
For example, in the Gambian sample, the four most common SNPs are selected first by the EMM (TNF-3025 (38%), TNF-308 (19%), TNF+851 (10%), TNF-1031 (11%)).
It is not surprising that the first few SNPs selected by the EMM are those that have frequencies closest to 0.50; however, the addition of a common SNP that is well correlated with a SNP already in the subset will contribute little additional information.
EMM conceived the study and evaluated the data.
The next most common SNPs are the TNF+1304 (9%) and the TNF-863 (6%); however, the EMM does not choose these SNPs next because the TNF+1304 tends to occur in phase with the TNF+851, and the TNF-863 tends to occur in phase with the TNF-1031, both of which are already in the subset of four SNPs.