Example sentences for: egf-like

How can you use “egf-like” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The interaction of EGF-modules with either non EGF-like modules (e.g.

  • It remains to be determined which of the regions within the EGF-like modules #5-9 (e.g.

  • The EGF-like modules found in fibulin-1 are instrumental in a variety of extracellular protein:protein interactions.

  • Fibulin-1 is a calcium-binding extracellular matrix glycoprotein that is associated with various connective tissues, basement membranes and blood [ 37 38 39 ] . Splicing of the C terminal domain of fibulin-1 can lead to the expression of different variants of fibulin-1 (A-D) [ 37 ] . The amino acid sequence of the human fibulin-1C protein encodes five domains: a signal sequence (35 amino acid residues), three anaphylatoxin type I repeats (108 residues), an adjoining sequence (33 amino acid residues), nine calcium-binding type II EGF-like modules (387 amino acid residues), and a carboxyl domain (116 amino acid residues) [ 37 ] . The amino acid sequence derived from the nucleotide sequence obtained for monkey fibulin-1C (GenBank accession number AF395659) shows it to share 97.

  • The amino acid sequence of the heparin-binding region of HB-EGF ( 21KRKKKGKGLGKKRDPCLRKYK 41) [ 2 ] has been shown to have a strong affinity for heparin and may influence the interaction of this growth factor with cell-surface negatively charged heparan sulfate proteoglycans [ 22 ] . It remains to be seen whether specific/all of the EGF-like modules are required and whether calcium is needed for the interaction of HB-EGF with LTBP-3.


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