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Example sentences for: eesssse

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By contrast, a deletion of twelve residues of the human alpha-2A receptor (293-304) which includes the EESSSSE motif did not appear to prevent agonist-induced down-regulation [ 26 ] . Thus a phosphorylation pathway may not be involved in agonist-induced down-regulation of the alpha-2A adrenergic receptor.
Similarly, mutation of only two serine residues in the human alpha-2A receptor resulted in a loss of desensitization [ 12 ] . Because the EESSSSE motif in the human alpha-2A receptor is a known GRK substrate, and because eliminating two potential phosphorylation sites prevents down-reguation, phosphorylation of the opossum alpha-2C receptor may be important in the mechanism of down-regulation of this receptor.