Words similar to ectodomain

Example sentences for: ectodomain

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The first evidence that APP might be a substrate for ectodomain shedding was provided by Weidemann et al.
In cell culture, lovastatin and simvastatin decrease the release of Aβ by rat hippocampal neurons [12,14] while activating α-secretase-type ectodomain shedding [15,16].
In early studies, the existence of the shed ectodomain of APP was used to deduce the existence of the proteolytic activity designated α-secretase, which has the unusual specificity of cleaving its substrates at a proscribed distance from the extracellular leaflet of the plasma membrane [4,39].
Surprisingly, and unlike with mAb 2F5 [ 8 ] specific for the C-terminal region of the gp41 ectodomain [ 33 ] , CAP treatment enhanced the binding of both HIV-1 IIIB and HIV-1 BaL to mAb NC-1, reacting with gp41 six-helix bundles from both HIV-1 IIIB and BaL (Fig.
α-Secretase-type ectodomain shedding divides the Aβ domain of APP, thereby generating α-secretase-cleaved soluble APP ectodomain (sAPP α ) [4].