Example sentences for: ectodomain

How can you use “ectodomain” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • In cell culture, lovastatin and simvastatin decrease the release of Aβ by rat hippocampal neurons [12,14] while activating α-secretase-type ectodomain shedding [15,16].

  • In the case of Notch, the process is set in motion by the binding of a ligand to the Notch ectodomain, triggering its release (shedding).

  • However, the molecular mechanisms by which statins modulate ectodomain shedding remain to be elucidated [17,18].

  • Despite this, however, the association of statins and cholesterol levels with activated α-secretase-mediated shedding of the APP ectodomain was unexpected and not readily explicable by existing knowledge regarding regulation of α-secretase activity.

  • It was intended to expand these studies to mAb NC-1, specific for the gp41 six-helix bundle [ 20 ] . Results of preliminary studies indicated that CAP did not interfere with the six-helix bundle formation from constituent peptides derived from near the N- and C-terminus of the gp41 ectodomain [ 20 ] ; (own unpublished data).


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