Example sentences for: ectodomain

How can you use “ectodomain” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The outer surface of the coiled-coil contains grooves into which three heptad repeat regions from the C-terminal part of the gp41 ectodomain pack, resulting in a stable six-helix bundle [ 42 45 46 47 48 49 50 51 52 53 54 ] . The six-helix bundle structure can be detected by specific antibodies [ 14 20 43 55 ] .

  • In our paper [2], we present evidence that the isoprenoid pathway contributes to statin-activated shedding of the APP ectodomain in cultured cells.

  • Despite this, however, the association of statins and cholesterol levels with activated α-secretase-mediated shedding of the APP ectodomain was unexpected and not readily explicable by existing knowledge regarding regulation of α-secretase activity.

  • More specifically, the data indicate that ROCK1 activation blocks the effects of statins on APP ectodomain shedding, while ROCK1 blockade alone can mimic the effect of statins on APP shedding.

  • However, the molecular mechanisms by which statins modulate ectodomain shedding remain to be elucidated [17,18].


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