Words similar to ectodomain

Example sentences for: ectodomain

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A smaller fraction of APP molecules (approximately 20% in PC12 cells under basal conditions [5]) undergoes ectodomain shedding catalyzed by either the α-secretase (nonamyloidogenic) or β-secretase (potentially amyloiodgenic) pathway.
In cell culture, lovastatin and simvastatin decrease the release of Aβ by rat hippocampal neurons [12,14] while activating α-secretase-type ectodomain shedding [15,16].
However, the molecular mechanisms by which statins modulate ectodomain shedding remain to be elucidated [17,18].
α-Secretase-type ectodomain shedding divides the Aβ domain of APP, thereby generating α-secretase-cleaved soluble APP ectodomain (sAPP α ) [4].
More specifically, the data indicate that ROCK1 activation blocks the effects of statins on APP ectodomain shedding, while ROCK1 blockade alone can mimic the effect of statins on APP shedding.