Words similar to ebp
Example sentences for: ebp
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It is possible that NF-κB and CREB mediate the early phases of neutrophil activation, while C/EBP proteins function to maintain this response [ 50 ] . The observation that the temporal pattern of expression of activated C/EBP and PKB-α are similar suggests co-ordinated regulation of these proteins [ 51 ] . A decrease in activation of transcription factors like NF-κB and CREB and an increase in C/EBP may also contribute to reduced activity of pro-apoptotic genes, resulting in prolonged longevity of neutrophils in the lung vasculature.
Clinical trials using the rapamycin analog CCI-779 show promise for this strategy [ 22 ] . Rapamycin and its synthetic analogs block mTOR kinase activity leading to dephosphorylation of 4EBP and other mTOR substrates.
BAL = bronchoalveolar lavage; BSA = bovine serum albumin; C/EBP = CCAAT/enhancer binding protein; COX-2 = cyclooxygenase-2; CREB = cAMP response element binding protein; FBS = fetal bovine serum; fMLP = n-formyl-methionyl-leucyl-phenylalanine; HBSS = Hank's balanced salt solution; ICAM-1 = intercellular adhesion molecule-1; LPS = lipoplysaccharide; MAP = mitogen activated protein; MIP-2 = macrophage inflammatory protein-2; NF-κB = nuclear factor-kappa B; PBS = phosphate-buffered saline; PI3K = phosphatidyl inositol 3 kinase; PKB = protein kinase B; RT-PCR = Reverse transcription-polymerase chain reaction; TBE = Tris borate EDTA; TNF-α = tumor necrosis factor alpha
Thus, whereas CREB activity peaked 0.5 hours after endotoxin administration, C/EBP binding activity was maximal at 12 hours.
Phosphorylation of 4EBP disrupts its ability to bind eIF4E, freeing eIF4E to bind eIF4G, which functions to recruit additional components of the initiation complex [ 7 8 ] . The net result is that phosphorylation of 4EBP enhances cap-dependent translation initiation.
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