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Example sentences for: eae

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Whatever the underlying reason(s) for the development of anaphylactic reactivity to these self peptide preparations, in both the EAE and the NOD T1DM models, anaphylactic reactions occurred in mice that had developed strong IgG1 responses to the relevant self peptides, with only modest changes in total IgE levels.
Thus, some of us recently showed that administration of two self peptides that can induce EAE, myelin proteolipid protein peptide 139 to 151 (PLP139-151) or myelin oligodendrocyte glycoprotein peptide 35-55 (MOG35-55), can result in severe anaphylactic reactions [ 14 ] . This result clearly indicated that severe allergic reactions to self peptides can occur in mice that have been induced to express pathology (i.e.
EAE participated in the design, generated the riboprobes, performed the cryosections, the in situ hybrdizations, and immunohistochemistry, and drafted the manuscript.
There were both similarities and differences between our findings in the NOD mouse model of T1DM and those in the EAE model [ 14 ] . Expression of EAE requires specific immunization with self peptides (e.g.
Thus, in both the EAE model [ 14 ] and the NOD T1DM model (this study, and that of Liu et al ., [ 15 ] ) some form of artificial "immunization" with a self peptide preparation appears to be required for the development of anaphylactic reactivity to "self".