Words similar to dosing
Example sentences for: dosing
How can you use “dosing” in a sentence? Here are some example sentences to help you improve your vocabulary:
Their dosing is limited by a ceiling effect, and they have a high risk of adverse effects.
Not all opioid analgesics that are commonly available are recommended for acute or chronic dosing.
Amprenavir (APV) is a potent protease inhibitor (PI) that is used in combination with other antiretroviral drugs for the treatment of antiretroviral-naïve and -experienced adults and children with HIV infection [ 1 2 3 4 5 ] . APV offers the convenience of twice-daily (BID) administration with no food or fluid restrictions [ 6 7 ] . Preclinical and clinical data suggest that APV has a lower potential to cause lipodystrophy and metabolic abnormalities than other currently available PIs [ 8 9 10 ] . APV has a distinct resistance profile that permits it to be considered as a treatment option for either PI-naïve or PI-experienced patients [ 11 ] . In a 64-week trial in treatment-naïve patients (NZTA4002; n = 302), APV 1200 mg, administered BID (APV1200) with one abacavir 300 mg tablet and one lamivudine 150 mg/zidovudine 300 mg combination tablet (Combivir ®), was as effective as nelfinavir 750 mg three times daily plus Combivir BID, with regard to the proportion of patients achieving HIV-1 RNA <40 copies/mL at week 64: 77% vs 66% (as-treated analysis) [ 12 ] . However, many patients in this trial withdrew prematurely because of adverse events that may have been, in part, related to the high pill burden (16 large 150 mg soft-gelatin capsules daily) associated with APV dosing and excipients contained in the APV formulation available at the time of the trial.
Opioid treatment for dyspnea is consistent with good medical practice, ethical when the intent is to relieve suffering, widely accepted when standard dosing guidelines are followed, and very unlikely to be associated with abuse behaviors [ 52 ] . As with pain treatment, pharmacological tolerance is not a clinically significant issue.
Area-under-the-curve monitoring gives an estimate of total drug exposure and may help minimize toxicity, particularly in patients with unusual clinical responses to standard dosing [ 20 ] . It would be useful to test this hypothesis in future studies.
Loading...