Words similar to dnp

Example sentences for: dnp

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Third, to our knowledge, our report provides the first controlled study demonstrating increased apoptosis specifically in PTECs in DNP with TED and IF.
Because CD36 protein was markedly increased in proximal tubules in human DNP, we examined the effects of high ambient glucose on CD36 mRNA and protein expression in the human PTEC line HK-2 (Figure 3).
Specifically, we show for the first time that both AGE and FFA PA induce PTEC apoptosis through CD36-mediated activation of src kinase, p38 MAPK, and caspase 3. Because high glucose stimulates CD36 expression in human PTECs and because CD36 expression is increased in apoptotic tubular epithelial cells in human DNP, we propose a two-step metabolic hit model relevant for TED, a hallmark of progression of human DNP.
Early abnormalities of DNP affect glomeruli and include an increase in glomerular filtration rate, microalbuminuria, glomerular hypertrophy, and thickening of the glomerular basement membrane, followed by expansion of mesangial extracellular matrix and glomerulosclerosis [1,2].
As with most chronic degenerative kidney diseases, the gradual decline of renal function at later stages of DNP is invariably associated with tubular epithelial degeneration (TED), also called tubular atrophy, and interstitial fibrosis (IF), hallmarks of degeneration to end-stage renal failure [3].