Words similar to divalent
Example sentences for: divalent
How can you use “divalent” in a sentence? Here are some example sentences to help you improve your vocabulary:
The predicted topological organization consists of six transmembrane domains with a hydrophobic loop between the fifth and sixth domain which lines the ion conducting pore [ 17 ] . VR1 has been expressed heterologously in several cell lines and has intrinsic sensitivity to thermal stimuli and to capsaicin (a pungent extract of the Capsicum pepper family) [ 18 ] . VR1 does not discriminate among monovalent cations [ 19 ] ; however, it exhibits a notable preference for divalent cations with a permeability sequence of Ca 2+> Mg 2+> Na +≈ K +≈ Cs + [ 9 ] . Ca 2+is especially important to VR1 function, as extracellular Ca 2+mediates desensitization [ 20 21 ] , a process which enables a neuron to adapt to specific stimuli by diminishing its overall response to a particular chemical or physical signal.
The presence of around 6 conserved acidic positions in the majority of the CYTH domains suggests that it coordinates two divalent metal ions.
Numerous factors determine the effect of mismatches, including: the length of the oligonucleotide, the nature and position of the mismatches, the temperature of hybridization, the presence of co-solvents and the concentrations of oligonucleotides, as well as monovalent and divalent cations [ 6 ] .
Since the interactions of Ca +2and Mg +2with proteins are difficult to study due to the lack of spectroscopic properties, vanadyl (V IV=O) 2+has been used as a probe of the ligands that compose Mg 2+, Ca 2+, and Mn 2+binding sites of several proteins, including carboxypeptidase [ 16 ] , S-adenosylmethionine synthetase [ 17 18 ] , pyruvate kinase [ 19 20 ] , and F 1 -ATPase [ 21 22 ] . This cation specifically binds to divalent cation binding sites of several enzymes, and in many cases serves as a functional cofactor [ 23 ] . Vanadyl has one axial and four equatorial coordination sites relative to the axis of the double-bounded oxygen, an arrangement that is similar to that for Ca 2+and Mg 2+.
We postulate that these enzymes are likely to chelate 2 divalent cations and are likely follow a bimetal reaction mechanism similar to what has been proposed for nucleotide cyclases, nucleic acid polymerases, or certain phosphoesterases such as those of the HD and DHH superfamilies.
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