Words similar to discrete
Example sentences for: discrete
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Rab proteins comprise a large family of Ras-related GTPases that function in the anterograde and retrograde trafficking of proteins in mammalian cells [ 1 2 3 ] . Different Rab proteins reside in specific subcellular membranes or organelles, where they mediate vesicular transport between discrete donor and acceptor compartments in the endocytic or exocytic pathways [ 4 5 ] . Detailed studies of a few Rab proteins ( e.g .; Rab1, Rab5 and Rab9) have led to a general model wherein Rab proteins are presumed to cycle on and off donor and acceptor membranes in connection with changes in their guanine nucleotide state [ 6 7 8 ] . In the active GTP-bound state, Rab proteins associate with budding transport vesicles [ 9 10 11 ] and appear to participate in the assembly of membrane docking complexes [ 12 13 14 ] . Following vesicle fusion with the acceptor compartment and GTP hydrolysis, the inactive GDP-bound Rab is extracted from the membrane by a carrier protein termed guanine nucleotide dissociation inhibitor (GDI) [ 15 16 17 ] . The GTPase can then re-enter the transport cycle through nucleotide exchange promoted by a specific exchange factor at the donor vesicle membrane [ 18 19 20 ] . In addition to changes in guanine nucleotide state, the posttranslational prenylation of Rab proteins plays an important role in the cycling mechanism.
The correspondence of CNCS clusters and functional enhancers is observed in other regions of the Drosophila genome, such as the discrete muscle-specific enhancer in the fourth intron of
Similarly, although circadian pacemaker cells in the Drosophila brain have been characterized anatomically as discrete clusters of cells called the Lateral Neurons [ 12 13 ] , the identity of clock cells in the tissues we studied is unknown.
This should result in the expression of encoded genes in target cells in an array format, in which each encoded gene should be expressed in a discrete cell spot while maintaining the original location of the viral vector spot in the virus array.
The application of USM as a tool for measuring scale-independent discrete sequence similarity and its particular application to genomics and proteomics exploits a distance metric providing an estimate of the length of similar regions surrounding a pair of symbols.
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