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Example sentences for: discoidin

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The earlier and more rapid loss of discoidin mRNA reinforces this conclusion as discoidin is a "pulse repressed" gene [ 42 ] .
Two secreted proteins or protein complexes are involved in sensing cell density [ 5 ] . Prestarvation factor (PSF) is a glycoprotein that is secreted when cells are growing and accumulates as an indicator of the ratio of cell density relative to the supply of food [ 6 7 ] . When the ratio of Dictyostelium cells to nutrients is above a certain threshold, PSF induces the expression of several early developmental genes including discoidin I, lysosomal enzymes, and some components of the cAMP pulsing system [ 8 9 ] . Once nutrients are depleted, PSF production declines and a second cell density-sensing pathway is activated.
In BS153 cells, discoidin mRNA was induced, reach maximum levels at 4 hour and rapidly decreased by 8 hours, the time mounds were formed (not shown).
Both the induction and subsequent loss of discoidin was 2 to 4 hours ahead of that in Ax4 cells.
The findings of earlier induction of these genes and ealier repression of discoidin are consistent with the observed early aggregation of BS153 cells.