Words similar to discoidin
Example sentences for: discoidin
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Both the induction and subsequent loss of discoidin was 2 to 4 hours ahead of that in Ax4 cells.
In BS153 cells, discoidin mRNA was induced, reach maximum levels at 4 hour and rapidly decreased by 8 hours, the time mounds were formed (not shown).
The findings of earlier induction of these genes and ealier repression of discoidin are consistent with the observed early aggregation of BS153 cells.
Two secreted proteins or protein complexes are involved in sensing cell density [ 5 ] . Prestarvation factor (PSF) is a glycoprotein that is secreted when cells are growing and accumulates as an indicator of the ratio of cell density relative to the supply of food [ 6 7 ] . When the ratio of Dictyostelium cells to nutrients is above a certain threshold, PSF induces the expression of several early developmental genes including discoidin I, lysosomal enzymes, and some components of the cAMP pulsing system [ 8 9 ] . Once nutrients are depleted, PSF production declines and a second cell density-sensing pathway is activated.
The earlier and more rapid loss of discoidin mRNA reinforces this conclusion as discoidin is a "pulse repressed" gene [ 42 ] .