Words similar to dihydroxyvitamin
Example sentences for: dihydroxyvitamin
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In these studies there was a significant increase in CaT1 mRNA levels at the lowest dose (10 -9mol/L) of 1,25-dihydroxyvitamin D studied (Figure 4), while a slightly higher level of CaT1 mRNA expression was observed at 10 -8mol/L 1,25-dihydroxyvitamin D, no further effect on CaT1 mRNA was seen with another 10-fold increase in 1,25-dihydroxyvitamin D concentration.
The rapid time course of induction and sensitivity of CaT1 mRNA response to 1,25-dihydroxyvitamin D treatment supports the idea that CaT1 could play a role as a gatekeeper of intestinal calcium absorption.
However, despite a considerable amount of associative evidence [ 7 ] , there has long been some controversy on this issue [ 29 30 31 ] because of apparent discrepancies in the temporal pattern of calbindin D9k induction compared to calcium absorption following 1,25-dihydroxyvitamin D treatment in experimental animals.
These observations are the first to demonstrate regulation of CaT1 expression by 1,25-dihydroxyvitamin D in the human enterocyte and are consistent with a new model of intestinal calcium absorption wherein vitamin D-mediated changes in brush border membrane CaT1 levels could be the primary gatekeeper regulating homeostatic modulation of intestinal calcium absorption efficiency.
In any case, the demonstrated effect of 1,25-dihydroxyvitamin D on CaT1 mRNA shown here in Caco-2 cells is consistent with the idea that the active metabolite of vitamin D could increase the number of CaT1 calcium transporters in the plasma membrane and could therefore be responsible for the higher rates of calcium influx seen across the brush border membrane in vitamin D-replete animals [ 9 27 ] thereby playing a key gatekeeper role in increasing the efficiency of intestinal calcium absorption and maintaining calcium homeostasis.
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