Example sentences for: dihydroxyvitamin

How can you use “dihydroxyvitamin” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The concentration of 1,25-dihydroxyvitamin D in the basal cell culture medium is approximately 10 -12mol/L.

  • If CaT1 is an important regulator of intestinal calcium absorption, it is likely that it would be regulated by 1,25-dihydroxyvitamin D. As shown in Figure 2, treatment of cells for 24 h with 10 -7mol/L 1,25-dihydroxyvitamin D caused a 10-fold increase (p < 0.001, ANOVA, n= 10 studies) in CaT1 mRNA expression.

  • This cell line spontaneously differentiates in culture and expresses biochemical and morphological characteristics of well-differentiated small intestine-like enterocytes [ 17 23 ] . We have previously shown that Caco-2 cells possess a classical nuclear vitamin D receptor [ 18 ] that directly mediates vitamin D-dependent gene expression [ 22 ] , and exhibits a high degree of specificity for various vitamin D metabolites and analogs [ 20 21 ] . Most importantly, in response to short-term (<24 h) 1,25-dihydroxyvitamin D treatment, Caco-2 cells increase transepithelial calcium transport [ 17 ] and calbindin D 9K expression [ 19 ] , a cytosolic calcium binding protein.

  • However, despite a considerable amount of associative evidence [ 7 ] , there has long been some controversy on this issue [ 29 30 31 ] because of apparent discrepancies in the temporal pattern of calbindin D9k induction compared to calcium absorption following 1,25-dihydroxyvitamin D treatment in experimental animals.

  • CaT1 and calbindin D 9K mRNA expression were normalized relative to the expression of GAPDH mRNA, a constitutively expressed gene whose levels were not affected by 1,25-dihydroxyvitamin D treatment.

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