Words similar to dihydroxyvitamin
Example sentences for: dihydroxyvitamin
How can you use “dihydroxyvitamin” in a sentence? Here are some example sentences to help you improve your vocabulary:
Treatment with 10 -7mol/L 1,25-dihydroxyvitamin D increased (~2-fold) CaT1 mRNA by 2 h, the earliest time point investigated, and clearly elevated CaT1 expression by 5-fold at 4 h, with progressively higher expression (up to 14-fold) at the later time points.
In addition, the different response to 1,25-dihydroxyvitamin D is also demonstrated in cultured human peripheral blood mononuclear cells from subjects with different Fok I genotypes [ 20].
Thus, in the current study, to evaluate a possible gatekeeper role for CaT1 in vitamin D-mediated calcium transport we compared the time course of 1,25-dihydroxyvitamin D induction of calbindin D9k mRNA and CaT1 mRNA in Caco-2 cells.
CaT1 mRNA is regulated by 1,25-dihydroxyvitamin D
Intestinal calcium absorption is increased after feeding a low calcium diet or under conditions of increased calcium needs, such as during growth, via a parathyroid hormone (PTH)-vitamin D mediated process [ 3 ] . A lowering of serum calcium levels stimulates the secretion of PTH that then activates the renal conversion of inactive 25-hydroxyvitamin D to the active hormonal metabolite 1,25-dihydroxyvitamin D. At the intestine, 1,25-dihydroxyvitamin D, acting through a nuclear receptor, stimulates transcription of vitamin D-mediated genes, including calbindin D, involved in calcium transport thereby acting as the primary hormonal regulator of active intestinal calcium transport [ 3 ] . It is thus likely that any putative key molecular player in calcium absorption, such as CaT1 or ECaC1, should be a prime target for hormonal regulation by 1,25-dihydroxyvitamin D. However, to date, neither CaT1 nor ECaC1 expression has been shown to be related to serum 1,25-dihydroxyvitamin D or vitamin D status [ 10 16 ] .
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