Words similar to diet-induced
Example sentences for: diet-induced
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Although the mechanisms through which adrenalectomy acts to reverse obesity is not entirely clear, it is plausible that the mechanisms entail enhanced hypothalamic POMC production [ 6 ] . Hypothalamic POMC mRNA is reduced in several forms of obesity [ 18 19 20 ] . Conversely, reversal of obese phenotypes by adrenalectomy is associated with a restoration of hypothalamic POMC mRNA tone in leptin-deficient ob/ob mice [ 6 ] . Furthermore, the melanocortin agonist MTII (which mimics the key anti-obesity product of POMC, alpha-MSH) reduces body weight in diet-induced obesity [ 21 ] . On the other hand, the effect of diet-induced obesity on hypothalamic POMC mRNA is somewhat complex and may depend on the genetic background [ 22 23 ] , and duration of the diet [ 24 25 ] or composition [ 23 ] of the diet.
In the present study, we observed that adrenalectomy did indeed lead to a remarkable enhancement of hypothalamic POMC mRNA tone in mice made obese on a high-fat diet; surprisingly, however, adrenalectomy did not reverse diet-induced obesity.
Since adrenalectomy only reduced plasma corticosterone by about 70% in the obese mice, rather than completely eliminating the steroid from circulation, it remains possible that even further reduction of corticosterone would produce an effect on diet-induced obese phenotypes.
In contrast to other models of obesity, however, diet-induced obesity was not associated with either elevated glucocorticoid levels or reduced hypothalamic POMC mRNA.
Thus neither adrenalectomy nor remarkable enhancement of hypothalamic POMC mRNA produced significant attenuation of the diet-induced obese phenotype.
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