Words similar to diet-induced
Example sentences for: diet-induced
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Although the mechanisms through which adrenalectomy acts to reverse obesity is not entirely clear, it is plausible that the mechanisms entail enhanced hypothalamic POMC production [ 6 ] . Hypothalamic POMC mRNA is reduced in several forms of obesity [ 18 19 20 ] . Conversely, reversal of obese phenotypes by adrenalectomy is associated with a restoration of hypothalamic POMC mRNA tone in leptin-deficient ob/ob mice [ 6 ] . Furthermore, the melanocortin agonist MTII (which mimics the key anti-obesity product of POMC, alpha-MSH) reduces body weight in diet-induced obesity [ 21 ] . On the other hand, the effect of diet-induced obesity on hypothalamic POMC mRNA is somewhat complex and may depend on the genetic background [ 22 23 ] , and duration of the diet [ 24 25 ] or composition [ 23 ] of the diet.
Although the diet-induced obese mice consumed more (calculated) calories than chow-fed mice during the first week on the diet (during which the most rapid weight gain was observed), by the fifth week they were hypophagic both in terms of mass of food consumed (g/day) and in calculated calories consumed (calories/day) (the chow sham-operated mice consumed 16.
The hypophagia of diet-induced obesity may be related to the modestly elevated hypothalamic POMC, whose product alpha-MSH is a known anorexic agent [ 20 29 ] . In turn, the induction of hypothalamic POMC by the high-fat diet might have been due in part to the elevation of leptin in diet-induced obese mice (Table I).
Nevertheless, with respect to the mechanism of diet-induced obesity, the present data seem to indicate that the diet-induced obese mice maintained their obesity despite apparently decreased caloric intake and increased caloric expenditure.
3A; p < 0.0001) and adrenalectomy led to a slight but statistical further increase in heat production in the diet-induced obese mice (Fib.
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