Words similar to diet-induced
Example sentences for: diet-induced
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Since adrenalectomy only reduced plasma corticosterone by about 70% in the obese mice, rather than completely eliminating the steroid from circulation, it remains possible that even further reduction of corticosterone would produce an effect on diet-induced obese phenotypes.
Although the mechanisms through which adrenalectomy acts to reverse obesity is not entirely clear, it is plausible that the mechanisms entail enhanced hypothalamic POMC production [ 6 ] . Hypothalamic POMC mRNA is reduced in several forms of obesity [ 18 19 20 ] . Conversely, reversal of obese phenotypes by adrenalectomy is associated with a restoration of hypothalamic POMC mRNA tone in leptin-deficient ob/ob mice [ 6 ] . Furthermore, the melanocortin agonist MTII (which mimics the key anti-obesity product of POMC, alpha-MSH) reduces body weight in diet-induced obesity [ 21 ] . On the other hand, the effect of diet-induced obesity on hypothalamic POMC mRNA is somewhat complex and may depend on the genetic background [ 22 23 ] , and duration of the diet [ 24 25 ] or composition [ 23 ] of the diet.
As has been observed in other models of obesity due to a high-fat diet, the diet-induced obese mice also became hypophagic compared to the chow fed mice and compared to the hyperphagia exhibited by mice in the first two weeks on a high fat diet [ 28 ] (Fig.
Thus neither adrenalectomy nor remarkable enhancement of hypothalamic POMC mRNA produced significant attenuation of the diet-induced obese phenotype.
Furthermore, the effect of adrenalectomy on hypothalamic POMC mRNA may also depend genetic background [ 6 26 27 ] . Nevertheless, we hypothesized that if adrenalectomy enhanced hypothalamic POMC mRNA in diet-induced obesity in mice, as in leptin-deficient mice, adrenalectomy would also reverse obese phenotypes in mice that became obese due to a high-fat diet.
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