Example sentences for: dicer

How can you use “dicer” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Second, there appears to be measurable selective pressure on the sequence of the non-miRNA arm, above and beyond the necessity to maintain a certain degree of helical structure that would make it a Dicer substrate.

  • The second mammalian RNase III orthologue also exhibits a single C-terminal dsRBM and tandem catalytic domains, but is otherwise structurally distinct from Dicer as it lacks the helicase and PAZ domains (Figure 1) [ 18 19 ] . Preliminary evidence indicates that this RNase III orthologue participates in rRNA maturation.

  • Similar to siRNAs, the natural small RNAs, dubbed microRNAs (miRNAs), arise from Dicer processing of dsRNA precursors and are incorporated into RISC (Denli and Hannon 2003).

  • The siRNAs are incorporated into a macromolecular complex which carries out degradation of homologous RNA sequences [ 14 ] . Dicer action serves to inhibit viral infection and retroposon movement, and also plays a role in developmental pathways by cleaving precursors to small regulatory RNAs (reviewed in [ 14 15 ] ). The predicted sequence of the mouse Dicer polypeptide exhibits a single dsRBM and tandem catalytic domains.

  • Sequence database searches and other studies [ 17 ] have revealed only two RNase III orthologues (Dicer and RNase III) in the mouse and human genomes.


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