Example sentences for: dgemric

How can you use “dgemric” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Accordingly, our goal was to use dGEMRIC to determine whether bovine cartilage explants briefly exposed to IL-1 would recover GAG at a uniform rate, or at a rate that depended on the degree of IL-1-induced GAG depletion.

  • Our group previously observed spatially uniform recovery of explants following trypsin-induced GAG depletion using dGEMRIC, with the increases in [GAG] occurring most rapidly during the first week and slowing considerably after 3 weeks [ 14 ] . Williams et al . [ 15 ] used the same method to monitor GAG accumulation in tissue engineered cartilage over 6 weeks, and observed relatively steady GAG accumulation over the entire period, with the bulk of the accumulation occurring at the periphery of the explant.

  • This dGEMRIC method of relating measured T1 and cartilage [GAG] was previously validated and reported [ 12 13 22 ] .

  • Use of dGEMRIC allowed for the actual [GAG] in the tissue to be followed over time.

  • The notion that the differential ability to replenish GAG fully is related to the differential state of the collagen matrix has been suggested by others, based in part on the finding that GAG depletion corresponds with regions that are positive for the col3/4 epitope, which is indicative of collagen damage [ 6 26 ] . Although we lack specific information on the state of the collagen matrix, the differences observed in the present study (and, indeed, the demonstrated ability to evaluate regional differences in response) suggest that dGEMRIC and model systems such as these may be useful for establishing a better understanding of the capacity of cartilage to repair osteoarthritis-like degradation.


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