Words similar to deubiquitination
Example sentences for: deubiquitination
How can you use “deubiquitination” in a sentence? Here are some example sentences to help you improve your vocabulary:
There is evidence that recycling of ubiquitin by the proteasome is indeed a crucial feature of deubiquitination in proper cellular maintenance (Legget et al.
This metalloprotease-like activity maps to the putative catalytic MPN+/JAMM motif of the lid subunit Rpn11 and lies at the heart of proteasome mechanism by linking deubiquitination with protein degradation.
However, this still does not explain the mechanistic rational for finding deubiquitination within the proteasome itself.
In principle, deubiquitination could be used for (1) recycling of ubiquitin, (2) abetting degradation by removal of the tightly folded highly stable globular ubiquitin domain, or (3) mitigating degradation by removal of the ubiquitin anchor, without which the substrate is easily released and rescued.
Distinguishing between options 2 and 3, however, depends to a large extent on the delicate balance between the two proteolytic activities associated with the proteasome: proteolysis and deubiquitination (Figure 2).