Example sentences for: deubiquitination

How can you use “deubiquitination” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Surprisingly, the proteasome itself harbors intrinsic deubiquitination activity (Eytan et al.

  • This metalloprotease-like activity maps to the putative catalytic MPN+/JAMM motif of the lid subunit Rpn11 and lies at the heart of proteasome mechanism by linking deubiquitination with protein degradation.

  • In principle, deubiquitination could be used for (1) recycling of ubiquitin, (2) abetting degradation by removal of the tightly folded highly stable globular ubiquitin domain, or (3) mitigating degradation by removal of the ubiquitin anchor, without which the substrate is easily released and rescued.

  • However, this still does not explain the mechanistic rational for finding deubiquitination within the proteasome itself.

  • 0 μg/mlMG-132 may be related to the sustained elevation of MPF activity noted in rat oocytes exposed to MG-132 [ 42 ] and the stabilization of polyubiquitinated proteins and enhanced deubiquitination of nucleosomal histones in chromatin following proteasomal inhibition [ 62 ] .

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