Example sentences for: deubiquitinating

How can you use “deubiquitinating” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • At first glance, the delegation of tasks between the proteolytic subunits of the proteasome (situated in the proteolytic core particle) and the auxiliary deubiquitinating enzymes (situated in the regulatory particle) is clear-cut: the latter cleave between ubiquitin domains, while the core proteolytic subunits process the target protein itself (Figure 1).

  • Overall, this protein certainly has properties consistent with a metallohydrolase and can serve as the prototype for the deubiquitinating enzymes in its class.

  • Based on sequence homology, deubiquitinating enzymes were traditionally classified into two families: ubiquitin-specific proteases (UBPs or USPs) and ubiquitin carboxy-terminal hydrolases (UCHs).

  • In groundbreaking work, an intrinsic “cryptic” deubiquitinating activity that is sensitive to metal chelators has been reported for the proteasome, in addition to “classic” cysteine protease behavior (Verma et al.

  • Interestingly, both “trimming” and “shaving” deubiquitinating activities are associated with the proteasome, though the exact contribution of the various proteasome-associated deubiquitinating enzymes to each of these distinct activities has yet to be elucidated.


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