Example sentences for: deubiquitinating

How can you use “deubiquitinating” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • It has been proposed that long polyubiquitin chains commit a substrate to unfolding and degradation by the proteasome, whereas short chains are poor substrates because they are edited by deubiquitinating enzymes, resulting in premature substrate release (Eytan et al.

  • Overall, this protein certainly has properties consistent with a metallohydrolase and can serve as the prototype for the deubiquitinating enzymes in its class.

  • Based on sequence homology, deubiquitinating enzymes were traditionally classified into two families: ubiquitin-specific proteases (UBPs or USPs) and ubiquitin carboxy-terminal hydrolases (UCHs).

  • Interestingly, both “trimming” and “shaving” deubiquitinating activities are associated with the proteasome, though the exact contribution of the various proteasome-associated deubiquitinating enzymes to each of these distinct activities has yet to be elucidated.

  • In groundbreaking work, an intrinsic “cryptic” deubiquitinating activity that is sensitive to metal chelators has been reported for the proteasome, in addition to “classic” cysteine protease behavior (Verma et al.


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