Words similar to desensitized

Example sentences for: desensitized

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The quantity of LH secreted by the anterior pituitary gland is the outcome of an interaction between the amount of hypothalamic GnRH secretion and the level of gonadotrope responsiveness to GnRH [ 7 ] . Quantitatively, gonadotrope responsiveness is more important than the level of GnRH secretion; for example, during the estrogen-stimulated preovulatory surge of LH secretion in the rat there is a 5-fold increase in GnRH secretion but a 50-fold increase in LH secretion [ 7 ] . Moreover, a quantity of GnRH that will evoke a normal preovulatory LH surge during the period preceding ovulation will induce only a small increase in LH secretion at other stages of the estrous cycle [ 7 ] . Similarly, termination of the preovulatory LH surge appears to be due to desensitization of the gonadotrope to GnRH action; in the sheep, a decrease in LH secretion precedes the decrease in GnRH secretion [ 41 ] , whereas in the rat, although the decrease in GnRH and LH secretion are co-incident [ 7 ] , there is evidence that the gonadotrope is already desensitized to GnRH [ 42 43 ] .
Lack of desensitization could result from either a stabilization of the open state of the channel or a destabilization of the desensitized state.
(His churchgoing heroine, Bethany, played by Linda Fiorentino, has become so desensitized to Vatican teachings that she works in an abortion clinic.)
While wt receptors desensitized rapidly, mutant receptors showed no desensitization during the 8 s perfusion time.