Example sentences for: desensitization

How can you use “desensitization” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The presence of spare 5-HT 2C receptors [ 27 ] in choroid plexus has also complicated the study of desensitization in vivo . However, it has been demonstrated that denervation of 5-HT neurons supersensitizes 5-HT 2C receptors [ 28 ] in choroid plexus, suggesting that these receptors are under tonic control by 5-HT.

  • Mammalian ORs are known to undergo rapid desensitization after odorant stimulation [ 56] and GRK3 has been implicated in this process [ 57, 58].

  • Westphal and colleagues [ 31 ] demonstrated that the 5-HT 2C receptor exhibits basal phosphorylation, and that agonist treatment was associated with increased phosphorylation and receptor desensitization in transfected cells.

  • The human alpha-2A adrenergic receptor has an acidic serine-rich motif (EESSSSD) in the third intracellular loop that has been shown to be important in agonist-induced desensitization but not in agonist-induced sequestration/internalization.

  • There are three subtypes of the alpha-2 adrenergic receptor: alpha-2A; alpha-2B; and alpha-2C [ 15 ] . The human alpha-2A subtype undergoes phosphorylation and short-term desensitization [ 11 12 ] , whereas the human alpha-2C subtype is not phosphorylated [ 16 ] and does not desensitize [ 11 ] . The human alpha-2C subtype, however, does undergo arrestin-dependent internalization [ 17 ] . Many studies [ 11 18 ] , including those from our laboratory [ 10 19 20 ] , have demonstrated agonist-induced down-regulation of alpha-2 receptors, although much less is known about the specific mechanisms for down-regulation as compared to the beta-2 receptor.

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