Words similar to desensitization
Example sentences for: desensitization
How can you use “desensitization” in a sentence? Here are some example sentences to help you improve your vocabulary:
That lengthy action means that, although nicotine activates the receptors, it then often turns particular receptor subtypes off again, a process called desensitization.
The quantity of LH secreted by the anterior pituitary gland is the outcome of an interaction between the amount of hypothalamic GnRH secretion and the level of gonadotrope responsiveness to GnRH [ 7 ] . Quantitatively, gonadotrope responsiveness is more important than the level of GnRH secretion; for example, during the estrogen-stimulated preovulatory surge of LH secretion in the rat there is a 5-fold increase in GnRH secretion but a 50-fold increase in LH secretion [ 7 ] . Moreover, a quantity of GnRH that will evoke a normal preovulatory LH surge during the period preceding ovulation will induce only a small increase in LH secretion at other stages of the estrous cycle [ 7 ] . Similarly, termination of the preovulatory LH surge appears to be due to desensitization of the gonadotrope to GnRH action; in the sheep, a decrease in LH secretion precedes the decrease in GnRH secretion [ 41 ] , whereas in the rat, although the decrease in GnRH and LH secretion are co-incident [ 7 ] , there is evidence that the gonadotrope is already desensitized to GnRH [ 42 43 ] .
Although β-adrenoceptor desensitization [ 23] or reduced ATPase activity [ 25] may account for the decrease in basal heart rate in the hypertrophied male hearts, the increased sensitivity to isoproterenol may support the hypotheses of ischemia-induced activation of β-adrenoceptor kinase [ 26] or modulation of G-protein signaling to preserve adenylate cyclase activity [ 27].
The expressed 5-HT 2C receptor exhibits homologous and heterologous desensitization in oocytes [ 32 ] mediated by protein kinase C [ 33 34 35 ] . A calmodulin-dependent kinase may also be involved in homologous desensitization [ 36 ] . In contrast, a recent study indicates that neither PKC nor calmodulin-dependent protein kinase II are involved, instead desensitization of the 5-HT 2C receptor is dependent on GRK activity [ 37 ] . Interestingly, tyrosine kinase involvement in the agonist-mediated phosphorylation of the rat 5-HT 2C receptor has also been reported [ 38 ] , although as yet no report has shown that the 5-HT 2C receptor directly activates tyrosine kinases.
The mechanisms underlying desensitization or down-regulation of the 5-HT 2C receptor are unknown but these reports suggest finely tuned control of 5-HT 2C receptor function and density.
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