Example sentences for: desensitization

How can you use “desensitization” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The molecular mechanisms involved in GnRH-induced desensitization are poorly understood, but they do not appear to be due to alterations in GnRH receptor expression [ 5 6 ] or to changes in LH concentrations in the pituitary gland [ 7 8 ] .

  • Although β-adrenoceptor desensitization [ 23] or reduced ATPase activity [ 25] may account for the decrease in basal heart rate in the hypertrophied male hearts, the increased sensitivity to isoproterenol may support the hypotheses of ischemia-induced activation of β-adrenoceptor kinase [ 26] or modulation of G-protein signaling to preserve adenylate cyclase activity [ 27].

  • Similarly, mutation of only two serine residues in the human alpha-2A receptor resulted in a loss of desensitization [ 12 ] . Because the EESSSSE motif in the human alpha-2A receptor is a known GRK substrate, and because eliminating two potential phosphorylation sites prevents down-reguation, phosphorylation of the opossum alpha-2C receptor may be important in the mechanism of down-regulation of this receptor.

  • Westphal and colleagues [ 31 ] demonstrated that the 5-HT 2C receptor exhibits basal phosphorylation, and that agonist treatment was associated with increased phosphorylation and receptor desensitization in transfected cells.

  • The alpha-2 adrenergic receptors also undergo agonist-induced desensitization and down-regulation.


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