Words similar to desensitization
Example sentences for: desensitization
How can you use “desensitization” in a sentence? Here are some example sentences to help you improve your vocabulary:
The mechanisms underlying desensitization or down-regulation of the 5-HT 2C receptor are unknown but these reports suggest finely tuned control of 5-HT 2C receptor function and density.
The human alpha-2A adrenergic receptor has an acidic serine-rich motif (EESSSSD) in the third intracellular loop that has been shown to be important in agonist-induced desensitization but not in agonist-induced sequestration/internalization.
The quantity of LH secreted by the anterior pituitary gland is the outcome of an interaction between the amount of hypothalamic GnRH secretion and the level of gonadotrope responsiveness to GnRH [ 7 ] . Quantitatively, gonadotrope responsiveness is more important than the level of GnRH secretion; for example, during the estrogen-stimulated preovulatory surge of LH secretion in the rat there is a 5-fold increase in GnRH secretion but a 50-fold increase in LH secretion [ 7 ] . Moreover, a quantity of GnRH that will evoke a normal preovulatory LH surge during the period preceding ovulation will induce only a small increase in LH secretion at other stages of the estrous cycle [ 7 ] . Similarly, termination of the preovulatory LH surge appears to be due to desensitization of the gonadotrope to GnRH action; in the sheep, a decrease in LH secretion precedes the decrease in GnRH secretion [ 41 ] , whereas in the rat, although the decrease in GnRH and LH secretion are co-incident [ 7 ] , there is evidence that the gonadotrope is already desensitized to GnRH [ 42 43 ] .
Yet another typical feature of many of these receptors is the presence of multiple serine and threonine residues in their carboxyl termini and IC3 that serve as phosphorylation sites for G-protein-coupled receptor kinases (GRKs) as well as protein kinases C (PKC) and A (PKA), a mechanism involved in agonist-dependent desensitization of the receptors.
Inevitably, desensitization sets in.
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