Example sentences for: desensitization

How can you use “desensitization” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Prolonged or repeated agonist stimulation of G protein-coupled receptors frequently causes a reduction in the response to the agonist [ 1 ] . Short-term agonist exposure results in desensitization that is characterized by a rapid (minutes) and reversible uncoupling of the receptor from the G protein followed by sequestration and/or internalization of receptors from the cell surface.

  • Desensitization kinetics were also altered.

  • Dowd declines to answer, but does propose a far-reaching "gross-out theory" in which politics and media, driven by America's gradual desensitization and need for stimulation, have fallen to new depths of tastelessness.

  • In vitro studies, carried out on NG108-15 neurohybrid cells which express large numbers of δ-opioid receptors, show that these receptors undergo a rapid agonist-induced desensitization that occurs within minutes and down-regulation that occurs more slowly over several hours ( 4, 7).

  • A near-universal feature of cell signaling via seven transmembrane, G protein-coupled receptors is attenuation of a cellular response upon prolonged exposure to an extracellular stimulus [ 1 ] . This desensitization process is well-established for GnRH-stimulated LH secretion from pituitary gonadotropes [ 2 3 ] , and occurs after about 6 h of continued exposure to GnRH in rats [ 3 ] ; removal of GnRH permits recovery from the profound suppression of LH secretion, albeit rather slowly (2-4 days; 4).


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