Words similar to desensitization
Example sentences for: desensitization
How can you use “desensitization” in a sentence? Here are some example sentences to help you improve your vocabulary:
The alpha-2 adrenergic receptors also undergo agonist-induced desensitization and down-regulation.
The predicted topological organization consists of six transmembrane domains with a hydrophobic loop between the fifth and sixth domain which lines the ion conducting pore [ 17 ] . VR1 has been expressed heterologously in several cell lines and has intrinsic sensitivity to thermal stimuli and to capsaicin (a pungent extract of the Capsicum pepper family) [ 18 ] . VR1 does not discriminate among monovalent cations [ 19 ] ; however, it exhibits a notable preference for divalent cations with a permeability sequence of Ca 2+> Mg 2+> Na +≈ K +≈ Cs + [ 9 ] . Ca 2+is especially important to VR1 function, as extracellular Ca 2+mediates desensitization [ 20 21 ] , a process which enables a neuron to adapt to specific stimuli by diminishing its overall response to a particular chemical or physical signal.
Inevitably, desensitization sets in.
Although β-adrenoceptor desensitization [ 23] or reduced ATPase activity [ 25] may account for the decrease in basal heart rate in the hypertrophied male hearts, the increased sensitivity to isoproterenol may support the hypotheses of ischemia-induced activation of β-adrenoceptor kinase [ 26] or modulation of G-protein signaling to preserve adenylate cyclase activity [ 27].
Site-directed mutagenesis studies indicate that all four of these serines are phosphorylated by GRK, and all four are needed for desensitization [ 12 ] . The influence of this motif on down-regulation was not investigated, however.
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