Words similar to desensitization

Example sentences for: desensitization

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A near-universal feature of cell signaling via seven transmembrane, G protein-coupled receptors is attenuation of a cellular response upon prolonged exposure to an extracellular stimulus [ 1 ] . This desensitization process is well-established for GnRH-stimulated LH secretion from pituitary gonadotropes [ 2 3 ] , and occurs after about 6 h of continued exposure to GnRH in rats [ 3 ] ; removal of GnRH permits recovery from the profound suppression of LH secretion, albeit rather slowly (2-4 days; 4).
Site-directed mutagenesis studies indicate that all four of these serines are phosphorylated by GRK, and all four are needed for desensitization [ 12 ] . The influence of this motif on down-regulation was not investigated, however.
The molecular mechanisms involved in GnRH-induced desensitization are poorly understood, but they do not appear to be due to alterations in GnRH receptor expression [ 5 6 ] or to changes in LH concentrations in the pituitary gland [ 7 8 ] .
In vitro studies, carried out on NG108-15 neurohybrid cells which express large numbers of δ-opioid receptors, show that these receptors undergo a rapid agonist-induced desensitization that occurs within minutes and down-regulation that occurs more slowly over several hours ( 4, 7).
That lengthy action means that, although nicotine activates the receptors, it then often turns particular receptor subtypes off again, a process called desensitization.