Words similar to desensitization
Example sentences for: desensitization
How can you use “desensitization” in a sentence? Here are some example sentences to help you improve your vocabulary:
The human alpha-2A adrenergic receptor has an acidic serine-rich motif (EESSSSD) in the third intracellular loop that has been shown to be important in agonist-induced desensitization but not in agonist-induced sequestration/internalization.
The presence of spare 5-HT 2C receptors [ 27 ] in choroid plexus has also complicated the study of desensitization in vivo . However, it has been demonstrated that denervation of 5-HT neurons supersensitizes 5-HT 2C receptors [ 28 ] in choroid plexus, suggesting that these receptors are under tonic control by 5-HT.
Desensitization kinetics were also altered.
Given the fact that the renal effects of low-dose dopamine in patients with sepsis syndrome decrease with time, it has been suggested that there is a desensitization of renal dopaminergic receptors [ 14].
The predicted topological organization consists of six transmembrane domains with a hydrophobic loop between the fifth and sixth domain which lines the ion conducting pore [ 17 ] . VR1 has been expressed heterologously in several cell lines and has intrinsic sensitivity to thermal stimuli and to capsaicin (a pungent extract of the Capsicum pepper family) [ 18 ] . VR1 does not discriminate among monovalent cations [ 19 ] ; however, it exhibits a notable preference for divalent cations with a permeability sequence of Ca 2+> Mg 2+> Na +≈ K +≈ Cs + [ 9 ] . Ca 2+is especially important to VR1 function, as extracellular Ca 2+mediates desensitization [ 20 21 ] , a process which enables a neuron to adapt to specific stimuli by diminishing its overall response to a particular chemical or physical signal.
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