Example sentences for: desensitization

How can you use “desensitization” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • While wt receptors desensitized rapidly, mutant receptors showed no desensitization during the 8 s perfusion time.

  • Cyclic nucleotide-gated channels, for example, appear to exhibit functional dimerization of their cyclic nucleotide-binding domains [ 32 ] . The "RCK" domain of BK channels has a dimerization domain even though BK channels, too, are tetrameric at the level of the pore [ 33 ] . Finally, the GluR2 ligand-binding core has a dimerization interface in the crystal structure [ 34 ] . Evidence, including the clustering of residues involved in receptor desensitization at this interface, suggests that the dimerization is not just crystallographic but functional.

  • Westphal and colleagues [ 31 ] demonstrated that the 5-HT 2C receptor exhibits basal phosphorylation, and that agonist treatment was associated with increased phosphorylation and receptor desensitization in transfected cells.

  • Lack of desensitization could result from either a stabilization of the open state of the channel or a destabilization of the desensitized state.

  • In vitro studies, carried out on NG108-15 neurohybrid cells which express large numbers of δ-opioid receptors, show that these receptors undergo a rapid agonist-induced desensitization that occurs within minutes and down-regulation that occurs more slowly over several hours ( 4, 7).


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