Example sentences for: depolarizing

How can you use “depolarizing” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • 2Ashows whole-cell Ca 2+currents in control, γ 1 het and γ 1 null myotubes in response to 500-ms depolarizing voltage steps from a holding potential of -40 mV.

  • Moreover, increasing the abundance of TRPC3 in cultured myotubes prolongs the period in which intracellular calcium is elevated following a depolarizing stimulus, sustains the transcription factor NFAT within the nucleus, and augments expression of NFAT-dependent target genes [40].

  • For post-tetanic γ oscillations, the slow depolarizations were mediated by tetanic stimulation-induced GABAergic depolarizing action [ 20 21 22 23 ] . This GABAergic depolarization is attributed to the tetanic stimulation-induced accumulation of intracellular chloride [ 24 ] and extracellular potassium [ 22 ] . For hyperthermic γ oscillations, heating causes a Na +/K +pump failure [ 8 ] , in turn resulting in the accumulation of intracellular Na +and Cl -, as well as extracellular K +, finally causing a slow membrane depolarization.

  • The results obtained here in skeletal muscle demonstrate that absence of the γ 1 subunit increases Ca 2+current density, decreases the inactivation rate, and shifts the voltage-dependence of inactivation in the depolarizing direction.

  • Whole-cell patch clamp currents recorded from a PGC-2 cell, in response to a series of six depolarizing test pulses of 1 s duration (step +20 mV) from a holding potential of -50 mV, before (left) and after (middle) application of 2 mM 4-aminopyridine (4-AP).


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