Example sentences for: depolarizing

How can you use “depolarizing” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Whole-cell patch clamp currents recorded from a PGC-2 cell, in response to a series of six depolarizing test pulses of 1 s duration (step +20 mV) from a holding potential of -50 mV, before (left) and after (middle) application of 2 mM 4-aminopyridine (4-AP).

  • Absence of ICa 2+was further verified using longer 500-ms depolarizing pulses (not shown).

  • Moreover, increasing the abundance of TRPC3 in cultured myotubes prolongs the period in which intracellular calcium is elevated following a depolarizing stimulus, sustains the transcription factor NFAT within the nucleus, and augments expression of NFAT-dependent target genes [40].

  • Absence of the γ 1 subunit slows inactivation and produces a depolarizing shift in the Ca 2+current inactivation vs. voltage curve, in agreement with results from an independently produced γ 1 knockout mouse [ 20].

  • The results obtained here in skeletal muscle demonstrate that absence of the γ 1 subunit increases Ca 2+current density, decreases the inactivation rate, and shifts the voltage-dependence of inactivation in the depolarizing direction.


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