Words similar to demonstrated
Example sentences for: demonstrated
How can you use “demonstrated” in a sentence? Here are some example sentences to help you improve your vocabulary:
We have previously demonstrated the overexpression and hormone-independent activation of the IGF-IR in primary breast cancers [ 42 ] . Similar overexpression of the IGF-IR and the ligands IGF-I and IGF-II have been seen in human gliomas and astrocytomas [ 43 44 45 46 ] . Because of the important role for the IGF-IR in cell survival, we investigated whether a dominant negative IGF-IR could inhibit growth of the U87 glioma.
Sisodia and colleagues [39] demonstrated that arrest of APP endocytosis from the plasma membrane by deletion of its NPXY clathrin-coated vesicle targeting sequence [40,41] can dramatically stimulate sAPP α shedding, presumably by extending the half-life of co-localized α-secretase and APP on the plasma membrane.
These studies corroborate previous studies that demonstrated that synovial T cells are enriched in IFN-γ-producing cells on initial isolation [ 11].
Several previous studies have demonstrated that CD7 loss is not a predictable marker for detection of MF/SS cells, as its expression is variable in this tumor type [ 15 19 ] . Although there is data to suggest that CD7-negative T-cells may represent a distinct differentiation pathway in normal and neoplastic helper T cells, [ 20 21 ] the variable expression of CD7 in MF/SS that we have observed suggests that this marker may be highly modulated by tumor microenvironment and/or treatment.
While most cytokine research has focused on cells of the immune system, other cell types produce cytokines including the epithelial cells of the lung [ 28 29 ] , retina [ 30 ] , and intestines [ 31 32 ] . Among the few studies involving the biliary system, it was demonstrated that cultured human intrahepatic duct epithelial cells produce functional IL-8 and MCP-1 (CCL2) [ 14 33 ] . Isolated human intrahepatic epithelial ducts expressed immunoreactive IL-6 when treated with IL-1β or phorbal myristate acetate [ 34 ] . Intracellular TNF-α mRNA and protein was detected in intrahepatic biliary duct cells in tissue sections [ 35 ] , but not in cultured intrahepatic epithelial cells; therefore, there was no clear demonstration that biliary epithelium secretes TNF-α.
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