Example sentences for: delag

How can you use “delag” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The nature of the 185delAG frameshift makes it difficult to determine if the apoptotic alterations seen are directly caused by the mutation or by downstream effects of it and certainly deserves further scrutiny.

  • Therefore, ovarian surface epithelial cell lines with and without the 185delAG BRCA1 mutation were used to ascertain whether the RING domain of the amino-terminal affected apoptosis.

  • SV-40 large T-antigen transfected human ovarian surface epithelial cell lines, MCC5 and HIO3261-77, were derived from women with and without a family history of breast/ovarian cancer, respectively [ 31 ] . While MCC5 cells were derived from a patient denoted as wild type BRCA1 status, HIO3261-77 cells were derived from a patient characterized as 185delAG mutated [ 39 ] . Dr. W. Bai (USF) kindly provided the MCF7 breast cancer carcinoma line.

  • The 185delAG mutation in the BRCA1 gene disrupts the zinc linker region of the amino-terminal RING domain.

  • In contrast, our data showed that the 185delAG mutation, affecting the amino-terminal domain of BRCA1, conferred an increased apoptotic response with no caspase pathway preferentially selected.

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