Words similar to dedifferentiation
Example sentences for: dedifferentiation
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Infection of cultured podocytes with replication incompetent HIV-1 demonstrated that HIV-1 gene expression leads to the proliferation and dedifferentiation of the infected podocytes [ 6 7 8 ] , recapitulating the phenotypes observed in HIVAN specimens [ 9 10 ] . Similarly, renal expression of replication incompetent HIV-1 proviral transgenes in mice and rats produces a proliferative renal lesion that is indistiguisable both histopathologically and clinically from human HIVAN [ 11 12 13 14 ] . These observations raise the possibility that HIV-1 gene products may interact with mitogenic pathways in infected renal epithelium to cause aberrant cell-cycle engagement.
Therefore, reversine and Msx1 appear to have a similar effect on mouse myoblasts, although no reports have yet addressed whether reversine might induce dedifferentiation of multinucleated myotubes.
This latter process, known as cellular dedifferentiation, is especially prominent in vertebrates with exceptional regenerative abilities, such as salamanders.
Proliferation and dedifferentiation of HIV-1 infected renal epithelium is singularly unique compared to the effects of HIV-1 infection in other non-lymphoid tissues.
For example, during salamander limb regeneration, cells from muscle, bone, cartilage, nerve sheath, and connective tissues participate in the dedifferentiation process to form a pool of proliferating progenitor cells known as the regeneration blastema (Figure 1) (Chalkley 1954; Bodemer and Everett 1959; Hay and Fischman 1961; Wallace et al.
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