Example sentences for: dedifferentiation

How can you use “dedifferentiation” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Infection of cultured podocytes with replication incompetent HIV-1 demonstrated that HIV-1 gene expression leads to the proliferation and dedifferentiation of the infected podocytes [ 6 7 8 ] , recapitulating the phenotypes observed in HIVAN specimens [ 9 10 ] . Similarly, renal expression of replication incompetent HIV-1 proviral transgenes in mice and rats produces a proliferative renal lesion that is indistiguisable both histopathologically and clinically from human HIVAN [ 11 12 13 14 ] . These observations raise the possibility that HIV-1 gene products may interact with mitogenic pathways in infected renal epithelium to cause aberrant cell-cycle engagement.

  • For example, during salamander limb regeneration, cells from muscle, bone, cartilage, nerve sheath, and connective tissues participate in the dedifferentiation process to form a pool of proliferating progenitor cells known as the regeneration blastema (Figure 1) (Chalkley 1954; Bodemer and Everett 1959; Hay and Fischman 1961; Wallace et al.

  • They then essentially starved the cells so that they shut down normal metabolic function, entering a "quiescent" state, in which dedifferentiation apparently occurs.

  • In this way, MEC-3 activates its own transcription, which probably prevents the dedifferentiation of the touch neurons.

  • 2000) showing that ectopic Msx1 expression, coupled with serum stimulation, is sufficient to induce cleavage, cellularization, and dedifferentiation of mouse myotubes.


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