Words similar to decreasing
Example sentences for: decreasing
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Fiber might affect the risk of breast cancer by decreasing estrogen levels; fiber binds estrogen excreted into the gastrointestinal tract and reduces enterohepatic circulation [ 17 18 ] . In addition, higher dietary fiber intake has been associated with higher plasma levels of sex-hormone-binding globulin, which can reduce the bioavailability of estrogens [ 19 ] . The potential mechanism of a protective effect of vegetable fat is more speculative: vegetable fat is a composite of multiple forms of fatty acids, some of which have been proposed to increase risk (such as C 18:2 n-6) whereas other specific fatty acids have been proposed to decrease risk (such as C 18:1 , the primary fatty acid in olive oil) [ 20 ] . More detail on the type and composition of the vegetable oil used is necessary to pursue this relation with greater precision.
However, a recently published report on this association, based on a prospective cohort of 28,283 post-menopausal women, described a trend of decreasing risk of pancreatic cancer with increased weekly aspirin use [ 30 ] .
Nevertheless, the increasing rate of diabetic ketoacidosis noted during the study period (Figure 1, more marked for total diabetic ketoacidosis than de novo diabetic ketoacidosis) is in contrast to the decreasing rate of de novo diabetic ketoacidosis and stable rate of total diabetic ketoacidosis noted for users of tacrolimus (Figure 2).
This is consistent with previous observations that M6P/IGF2R knockout mice displayed generalized increased growth and cardiomygaly (resulting from cardiac myocyte hyperplasia) [ 34 ] , and that antisense-mediated reduction of M6P/IGF2R expression enhances tumorigenicity in JEG-3 cells [ 43 ] . Thus, loss or mutation of M6P/IGF2R may contribute to development and progression of tumors via different pathways: by increasing the mitogenic activity of IGF-II and decreasing the apoptotic signaling of TGF-β and lysosomal proteases.
Maximal IL-4 expression was detected on day 7, with the level gradually decreasing over time (Fig.
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