Words similar to deafness
Example sentences for: deafness
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Mutations in TMC1 are responsible for the autosomal dominant human hearing disorder DFNA36 and for the recessive deafness DFNB7/11 [ 5 ] ; the corresponding murine gene Tmc1 also causes deafness in the mutant mouse strains Beethoven ( Bth ) and deafness ( dn ) [ 6 ] . Bth / Bth mice display altered potassium currents in early postnatal cochlear hair cells, in particular Ik,n and Ik,f currents appear to be depressed [ 10 ] . This observation led to the hypothesis that Tmc1 may participate directly or indirectly in regulating the permeability of potassium channels [ 10 ] . Because of the high level of conservation of the amino acid sequences among the eight mammalian TMC proteins (Figure 1, Additional file 1), we speculate that other TMC proteins may as well be modifiers of ion channels or transporters.
However, the ear, and in particular the cochlea, or inner ear, can be damaged by exposure to excess noise, leading to permanent damage to the ear, i.e., deafness.
3 confers susceptibility to Schizophrenia in the British population but not in the Japanese population [ 39 ] . Genetic heterogeneity is very common in hereditary deafness [ 40 ] ; also the prevalence of mutations in the connexin 26 gene is a major cause of non-syndromic autosomal recessive deafness that varies in different populations [ 41 ] .
Indeed, a rapid search of the Online Mendelian Inheritance in Man database (OMIM [ 18]) for genes associated with the terms 'severe' and 'disorder' confirmed that mutations of GALC, LAMB3, GJB2, JAG1, TGFBI, LPL and LDLR were the origin of serious disorders: Krabbe disease, Herlitz junctional epidermolysis bullosa, autosomal dominant deafness - Vohwinkel syndrome, Alagille syndrome, corneal dystrophy, type I hyperlipoproteinemia and hypercholesterolemia, respectively.
"The genetic code in the chromosome is thought to contain vital information on several hereditary conditions, including schizophrenia and deafness," the Sunday Telegraph of London said.
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