Words similar to deafness
Example sentences for: deafness
How can you use “deafness” in a sentence? Here are some example sentences to help you improve your vocabulary:
The first set of genes, transmembrane cochlear expressed genes 1 and 2 ( TMC1 ) and TMC2 [ 5 ] were found in a search for mutations causing dominant and recessive deafness in human and mouse [ 5 6 ] . Mutations in the second pair of genes, EVER1 and EVER2 , are linked to epidermodysplasia verruciformis that is associated with an increased susceptibility to infection with some human papillomaviruses causing a high risk of skin carcinoma [ 7 ] . We noticed that the proteins encoded by these genes are homologous, which raised our interest in testing whether the genome accommodates additional related genes.
Disease severity does not seem to affect this complication: deafness may develop in mild as well as in severe cases.
Still, most have happily been kept at bay: we still have not suffered from, among others, the King's Evil, insufficient flow of milk, St. Vitus [ sic ] dance, deafness, or salt rheum; the others, including felons, come and go and must be regarded as natural reflections of everyday life.
Mutations in TMC1 are responsible for the autosomal dominant human hearing disorder DFNA36 and for the recessive deafness DFNB7/11 [ 5 ] ; the corresponding murine gene Tmc1 also causes deafness in the mutant mouse strains Beethoven ( Bth ) and deafness ( dn ) [ 6 ] . Bth / Bth mice display altered potassium currents in early postnatal cochlear hair cells, in particular Ik,n and Ik,f currents appear to be depressed [ 10 ] . This observation led to the hypothesis that Tmc1 may participate directly or indirectly in regulating the permeability of potassium channels [ 10 ] . Because of the high level of conservation of the amino acid sequences among the eight mammalian TMC proteins (Figure 1, Additional file 1), we speculate that other TMC proteins may as well be modifiers of ion channels or transporters.
Mutations in DDP1 (deafness/dystonia peptide 1) lead to deafness-dystonia.
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