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Example sentences for: dctx
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The levels of the three CTX isoforms α L, β Land α Dwere 2.3-fold to 2.7-fold higher in the postmenopausal women (Table 1), in accordance with previous reports of CTX levels during the menopause [ 15 ] . As all forms were elevated to the same magnitude in postmenopause, the ratios between the newly synthesised α LCTX form and the older β Land α DCTX forms was not significantly different in premenopausal and postmenopausal women.
When individual Z scores of CTX were calculated for the metastatic breast cancer patients compared with the non-metastatic patients, the α LCTX form and the α L/α DCTX ratio showed the highest average increases in accordance with the ability of the α LCTX levels and the α L/α DCTX ratio to most sensitively reflect alterations in the balance between the anabolic and catabolic processes of bone turnover (Fig.
The age-related β Lform accumulates with a slightly higher kinetic rate than α DCTX [ 9 ] . This is also apparent from the less pronounced increase in the α L/β Lratio compared with the α L/α Dratio in metastatic patients.
For the β Land α DCTX markers, respectively, 47 and 48% of the metastatic patients had levels 2 SDs above the reference level of nonmetastasised controls (Fig.
This is in good agreement with kinetic studies of the isomerisation and racemisation reactions, where it was shown that the α DCTX form accumulates with the lowest kinetic rate [ 9 ] . The α L/α DCTX ratio will thus be most affected by changes of bone turnover processes influencing the half-life of collagen type I in the bone matrix.
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