Words similar to d-akap

Example sentences for: d-akap

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Only recently has the subcellular distribution of PKA at neuromuscular junctions (NMJs) and the adjacent muscle been systematically studied [ 17 18 ] . Imaizumi-Scherrer and colleagues demonstrated that RIα is localized at the NMJ [ 19 ] , but whether RI associates with a D-AKAP in this region of muscle is not known.
We observed an enrichment of D-AKAP1 at the postsynaptic membrane, as shown by codistribution with nAChR (fig.
Our interest in PKA and PKC activity in the NMJ derives from: (1) a report that RIα not only is enriched there, but also appears to be tethered to the postsynaptic membrane [ 19 ] , (2) the rich literature describing selective PKC isoform activity and functional compartmentalization in the NMJ and skeletal muscle, (3) our discoveries that D-AKAP1 and D-AKAP2 bind to and appear to colocalize with RIα, and often mitochondria [ 15 16 28 ] ; and (4) our finding that gravin binds to both PKA and PKC [ 13 ] .
Because RIα was observed in close association with the NMJ postsynaptic membrane [ 19 ] , we probed for D-AKAP expression and possible colocalization with this and other regulatory subunits.
D-AKAP1 codistribution with cytochrome c (mitochondrial marker) is significant (fig.