Words similar to d-akap
Example sentences for: d-akap
How can you use “d-akap” in a sentence? Here are some example sentences to help you improve your vocabulary:
In our previous immunofluorescence work examining D-AKAP2 subcellular localization, the protein displayed a diffuse background in addition to mitochondrial staining [ 29 ] . It was thought that the combination of specific and diffuse labeling indicated the presence of more than one pool of D-AKAP2 inside the cells examined.
Consistent with the observed mitochondrial staining by anti-D-AKAP1, it was shown previously that one of the two alternative NH2-terminal motifs of this AKAP is necessary and sufficient for targeting to mitochondria [ 28 ] . Interestingly, another AKAP governs voltage-dependent potentiation of L-type calcium channels through anchoring of PKA in transverse tubules [ 36 ] . Because this potentiation is not dependent on RIIα, it is thought that RIα is capable of this AKAP-directed modulation of calcium channel activity [ 37 ] .
An example is the association of D-AKAP2 with mitochondria in cultured myocytes [ 29 ] that is not present in muscle tissue (fig.
A band for RIIβ was detected in contrast to a report of no RIIβ detection in soleus or extensor digitorum longus muscles [ 18 ] , which might be explained by the presence of nerve fibers or adipocytes wherein RIIβ is prevalent [ 27 ] . The blot for the affinity-purified D-AKAP1 antibody is shown because the protein-A purified antibody displayed additional, unexplained bands; however, no difference in fluorescence labeling was observed when using antibodies purified either way.
Because the labeling patterns for RIα and D-AKAP1 appear similar in the muscle fibers and at the postsynaptic membrane, D-AKAP1 may anchor RIα in these regions, which further supports the cloning and biochemical evidence of interaction between these proteins [ 15 28 ] . Phalloidin was used as a positive control for the actin region of muscle fibers (fig.
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