Words similar to cutpoint
Example sentences for: cutpoint
How can you use “cutpoint” in a sentence? Here are some example sentences to help you improve your vocabulary:
Lowering the PSA cutpoint below 4 ng/ml increased test sensitivity but markedly decreased specificity.
Some investigators are now recommending that lower PSA cutpoints should be used as an indication for prostate biopsy [ 37 38 39 ] . Catalona and colleagues detected cancer in 22% of men biopsied with PSA levels between 2.6 to 4 ng/ml [ 37 ] and Lodding and colleagues detected cancers in 13% of men with PSA values between 3 to 4 ng/ml [ 39 ] . We found that lowering the cutpoint to 2 ng/ml, while greatly increasing sensitivity, led to an 80% false positive rate.
Estimates for sensitivity, specificity, and predictive values for different PSA cutpoints, stratified by age range, are reported in Tables 1and 2. Data are presented for men in their 50s and 60s in Table 1, and for men in their 70s and all age groups combined (including men in their 40s and men 80 years and older) in Table 2. For the standard PSA cutpoint of 4 ng/ml, test sensitivity was 86% and specificity was 33%.
At this cutpoint the likelihood ratio for a positive test was 1.19 (95% CI 1.15 to 1.22) and 0.25 (95% CI 0.19 to 0.34) for a negative test.
Overall, however, the magnitudes of the likelihood ratios with age-specific reference ranges were similar to those found with the 4 ng/ml cutpoint, except for higher likelihood ratios following negative tests in men 70 years and older.