Example sentences for: culminate

How can you use “culminate” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Arab newspapers are now warning their readers that the current escalation of United States airstrikes on Iraq could culminate in a major military offensive aimed at bringing down President Saddam Hussein.

  • In May, the Justice Department began shaping plans for building a budget for fiscal year 2003, the process that would usually culminate in an administration proposal at the beginning of 2002.

  • These signaling pathways culminate in the activation of specific transcription factors, so that there must be both shared target genes, as well as genes unique to antigen or IL-2 signaling.

  • SLC/CCL21, normally expressed in high endothelial venules and in T cell zones of spleen and lymph nodes, strongly attracts T cells and dendritic cells (DC) [ 1 2 3 4 5 6 7 8 ] . SLC/CCL21 recruits both naïve lymphocytes and antigen stimulated DC into T cell zones of secondary lymphoid organs, co-localizing these early immune response constituents that culminate in cognate T cell activation [ 1 ] . The capacity to facilitate the co-localization of both DC and T cells forms a strong rationale for the use of SLC/CCL21 in cancer therapy.

  • In contrast, complex stimuli, such as sugars, amino acids, and most bitter compounds bind to G protein coupled receptors, initiating intracellular signaling cascades that culminate in Ca 2+influx or release of Ca 2+from intracellular stores [ 1 2 3 ] .


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