Words similar to cullin
Example sentences for: cullin
How can you use “cullin” in a sentence? Here are some example sentences to help you improve your vocabulary:
With respect to the recent implication of CSN in cullin regulation [ 10], we considered the possibility that the overlapping phenotypes of csn1 and pcu3 mutants could arise from interference with Pcu3p function.
It is likely that some subunits have very specialized functions within the complex, while others are required for its broader activities such as control of cullin neddylation.
Our data confirm and extend the recently discovered connection between CSN and cullin regulation [ 10] by showing that deletion of four putative CSN subunits causes accumulation of Pcu3p in the neddylated state (Fig.
Studies in budding yeast identified SCF Cdc4p, an E3 ubiquitin ligase complex that mediates the ubiquitylation of the CDK inhibitor Sic1p [ 3 4 ] . SCF Cdc4pconsists of at least four proteins: the cullin Cdc53p, the RING domain protein Hrt1p/Rbx1p/Roc1p, the adapter protein Skp1p, and Cdc4p (reviewed in [ 1 ] ). Cdc4p contains two sequence motifs, which are conserved in a wide variety of so-called F-box proteins: C-terminal WD-repeats that are involved in binding the substrate Sic1p in a phosphorylation-dependent manner, and a central F-box [ 5 ] that interacts with Skp1p [ 6 7 ] . Cdc53p in turn binds to Skp1p and Hrt1p/Rbx1p/Roc1p, which bridges Cdc53p with the ubiquitin-conjugating enzyme Cdc34p/Ubc3p [ 6 8 9 10 11 12 ] . In vitro reconstitution demonstrated that SCF Cdc4p, Cdc34p, E1, ubiquitin, and ATP are sufficient to mediate Sic1p polyubiquitylation [ 6 7 ] .
The cullin/RING family of ubiquitin ligases comprises a multifunctional set of enzymes controlling the stability and activity of cell cycle regulators, transcription factors, and signaling proteins (reviewed in ref.
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