Example sentences for: cullin

How can you use “cullin” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • 2A, and data not shown), also suggests that control of cullin neddylation results from cooperation of multiple CSN components rather than from the activity of a single catalytic subunit.

  • SCF = SKP1/Cullin/F-box protein complex

  • COP10, which has been shown to interact with AtCOP1 in yeast two-hybrid experiment, encodes a ubiquitin conjugating enzyme (E2) variant [ 44 ] . The COP9 signalosome, an eight-subunit complex homologous to the lid subcomplex of the 26 S proteasome [ 45 ] , directly associates with SCF E3 complex and promotes deneddylation of the cullin subunit of SCF in both plant and animal cells [ 46 47 48 49 ] . The exact relationship between COP1 and the COP9 signalosome remains obscure; it is known, however, that in Arabidopsis the COP9 signalosome is required for COP1 to accumulate in the nucleus in the dark [ 29 ] . Although COP1 most likely plays a role in regulating protein degradation, attempts in reconstituting ubiquitination of HY5 by AtCOP1 have been unsuccessful.

  • recently provided evidence for a cullin deneddylating activity of CSN by demonstrating that a partially purified preparation of the pig CSN can deneddylate the fission yeast cullin Pcu1p in vitro [ 10].

  • With respect to the recent implication of CSN in cullin regulation [ 10], we considered the possibility that the overlapping phenotypes of csn1 and pcu3 mutants could arise from interference with Pcu3p function.


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