Words similar to cullin
Example sentences for: cullin
How can you use “cullin” in a sentence? Here are some example sentences to help you improve your vocabulary:
SCF complexes are E3s composed of the Cullin family member Cul1 (Cdc53 in S. cerevisiae ), as well as, Skp1, Roc1 (also called Rbx1 or Hrt1) and one of the numerous F-box proteins that act as a receptor for the substrate (for review see [ 2 ] ).
Regardless of the exact mechanism, CSN may regulate the activity of multiple cullin ubiquitin ligases through counteracting their stimulatory Ned8p modification.
Among the best studied examples of cullin/RING enzymes are the so-called SCF complexes.
In particular, one subunit—Csn5—moderates SCF (Skp1–cullin–F box) and other cullin-based E3 ubiquitin ligases by removal of the ubiquitin-like Rub1/Nedd8 molecule from the cullin subunit of the ligase complex.
This mutant accumulates Pcu1p exclusively in a form carrying the stimulatory Nedd8p modification, due to a defect in COP9/signalosome-mediated cullin deneddylation [ 24 25 ] . Replacing wild-type ubiquitin by a mutant lacking all lysine residues prevented the formation of high molecular weight products (Fig.
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