Words similar to cul
Example sentences for: cul
How can you use “cul” in a sentence? Here are some example sentences to help you improve your vocabulary:
The Drosophila Cul1 mutant is less useful because maternal contributions of Cul1 are so large that homozygous mutant animals develop to pupariation.
Inhibition of Ci processing can be scored by the accumulation of a C-terminal epitope [ 26 ] . This assay showed that reduction in the function of Slimb or Roc1, two activities that contribute to SCF function, is associated with an increase in Ci staining [ 26 ] [ 27 ] . Similarly, reduction of Cul1 function by mutation in Cul1 (data not shown and [ 28 ] ) or by overexpressing mCul1 (fig.
In addition to the key roles in E3 ligase activity, RING finger domains have also been shown to be important for regulating subcellular localization of E3s and/or their substrates in a number of cases [ 53 54 55 56 ] . Studies have shown the MDM2 RING finger domain is required to promote nuclear export of p53 and this activity of MDM2 RING finger seems to be coupled with its ability to promote ubiquitination of p53 [ 53 54 55 ] . Rbx1/ROC1, the small RING finger subunit of the SCF E3 complexes, promotes the nuclear accumulation of Cul1, another subunit of the SCF complexes [ 56 ] . These studies have suggested a correlation between the ubiquitination activities of RING fingers and their roles in regulating subcellular localization of the E3 ligases which they are part of.
It has been inferred that a deficit in Cul1 function results in defects in turn-over of specific proteins and that the phenotype varies between systems because of differences in the spectrum of proteins affected and differences in the importance of the targeted proteins.
To directly assess Cul1 function, we sought a target protein whose destruction might be limited by the activity of the Cul1/proteasome pathway.
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