Example sentences for: cul

How can you use “cul” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The cell death that occurred upon reduction of Cul1 function was suppressed when E2F function was reduced by mutation.

  • Additionally, unlike the spatially restricted expression of mCul1, the strong Cul1 mutant alleles result in lethality.

  • NEDD8 modification stimulates SCF-dependent substrate ubiquitylation in vitro [ 2, 3, 4], and mutant CUL1 resistant to NEDD8 modification is defective in vivo [ 5].

  • Based on the strength of the phenotype and its enhancement by removal of an endogenous copy of Cul1, we infer that the mCul1 expression only partially suppresses Cul1 function to create a hypomorphic phenotype.

  • In addition to CUL1, the human genome contains at least five other cullins, CUL 2, 3, 4A, 4B, and 5. This diversity is partially recapitulated in S. pombe , which encodes pcu3 and pcu4 , homologues of human CUL3 and CUL4, for which there are no direct correlates in budding yeast [ 6].


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