Words similar to cul
Example sentences for: cul
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Identification of fly Cul1 and Skp1 orthologs
Because SCF complexes are involved in controlling protein degradation, we favoured the hypothesis that Cul1 promotes the destruction of E2F and that the inappropriate persistence of E2F leads to cell death.
Several lines of evidence suggest that the SCF pathway is also conserved in the fission yeast Schizosaccharomyces pombe . Pcu1p, a Cdc53p/CUL1-related protein, was shown to associate with two different F-box/WD repeat proteins, Pop1p and Pop2p, when overexpressed [ 18 ] . In addition, genetic studies demonstrated that both of these F-box proteins are simultaneously required for efficient destruction of Rum1p and the replication initiator Cdc18p [ 18 19 20 ] . Rum1p is a Sic1p-analogous CDK inhibitor, which accumulates in G1, but is degraded as cells enter S phase [ 21 22 ] . Failure to degrade Rum1p is the major phenotypic defect of pop1 and pop2 deletion strains, which leads to disturbance of normal cell cycle progression, resulting in polyploidy [ 18 19 20 23 ] . Based on the genetic data and the biochemical observation that Pop1p and Pop2p interact when overexpressed, a putative SCF Pop1p-Pop2pcomplex was proposed, which would contain the heterooligomerizing F-box proteins Pop1p and Pop2p bound to SCF core components [ 18 20 ] .
In contrast, decreasing the level of endogenous Cul3 / guftagu (another Cullin family member, see http://flybase.bio.indiana.edu/) or expressing a GFP marker had no effect.
Expression of this cDNA in yeast is able to rescue the cdc53-1 mutation (not shown) indicating that the protein can perform at least some of the functions of the yeast Cul1.
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