Words similar to cul
Example sentences for: cul
How can you use “cul” in a sentence? Here are some example sentences to help you improve your vocabulary:
These data show that overexpression of mouse Cul1 has a dominant negative effect on Cul1 function, or that dCul1 suppresses a neomorphic activity of mCul1 .
The cell death that occurred upon reduction of Cul1 function was suppressed when E2F function was reduced by mutation.
Biochemical studies identified SCF SKP2, an E3 that mediates p27 ubiquitylation in vitro [ 20 21 ] . This complex consists of at least four proteins: SKP1, CUL1, HRT1 (=RBX1/ROC1), and SKP2.
In addition to CUL1, the human genome contains at least five other cullins, CUL 2, 3, 4A, 4B, and 5. This diversity is partially recapitulated in S. pombe , which encodes pcu3 and pcu4 , homologues of human CUL3 and CUL4, for which there are no direct correlates in budding yeast [ 6].
The essentially complete suppression of the mCul1 phenotype by reduction of the genetic dose of E2F suggests a remarkable level of specificity, in which, among the many targets of Cul1 action, the destruction of E2F appears to be particularly important.
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