Words similar to ctx
Example sentences for: ctx
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The levels of the three CTX isoforms α L, β Land α Dwere 2.3-fold to 2.7-fold higher in the postmenopausal women (Table 1), in accordance with previous reports of CTX levels during the menopause [ 15 ] . As all forms were elevated to the same magnitude in postmenopause, the ratios between the newly synthesised α LCTX form and the older β Land α DCTX forms was not significantly different in premenopausal and postmenopausal women.
The urinary excretion of all CTX forms was significantly higher ( P < 0.001) in the postmenopausal group when compared with the premenopausal women, with approximately 2.5-fold higher levels (Table 1).
The assay has been described elsewhere [ 9 ] . All determinations of urinary CTX were corrected for creatinine.
It has been shown that in Paget's disease of bone, a condition characterised by a localised upregulation of bone turnover, there is a significant increase in the ratio between the native peptide form of CTX (α L) and the age-modified forms (β L, D-isoaspartyl peptide and α D) [ 9 ] . The use of CTX ratios may thus be indicative of the significant decrease in the residence time and therefore the average age of the resorbed bone collagen type I fragments in Pagetic patients [ 9 ] . This indicates that perturbations in the normally well-regulated process of bone turnover can result in changes in the half-life of collagen type I within the bone matrix.
Paul Cloos, Stephan Christgau and Per Qvist are employees of Nordic Bioscience A/S, which commercializes the CTX immunoassays.