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Example sentences for: ctx
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The urinary concentration of all four CTX isoforms was initially measured in reference populations of healthy premenopausal and postmenopausal women.
The measurement of CTX isoforms, and the ratios between the native α Lform and the age-modified forms of CTX, indicative of the age of the resorbed collagen fragments, may thus provide clinical useful information for diagnosing and monitoring bone metastasis occurrence in cancer patients [ 11 ] . Such an application of the CTX bone resorption markers may be especially relevant for breast cancer patients, who have a high risk of developing bone metastases.
This in turn will result in increased amounts of the newly synthesised α LCTX form in the circulating pool of CTX fragments that is reflected in the elevated ratios [ 9 10 11 ] .
The levels of the three CTX isoforms α L, β Land α Dwere 2.3-fold to 2.7-fold higher in the postmenopausal women (Table 1), in accordance with previous reports of CTX levels during the menopause [ 15 ] . As all forms were elevated to the same magnitude in postmenopause, the ratios between the newly synthesised α LCTX form and the older β Land α DCTX forms was not significantly different in premenopausal and postmenopausal women.
The ability of the various CTX forms and CTX ratios to discriminate between patients with bone metastases (HC+ patients and NC+ patients) and patients without bone metastases (NC- patients) was assessed by Z -score analysis using the mean and SD of the NC- patient group (Fig.
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