Words similar to cryptochromes

Example sentences for: cryptochromes

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The expression of circadian genes that are regulated by cryptochromes were evaluated in the brain of cry1,2 -/-mice and in sleep deprived wild type mice and rats.
Deletion of the cryptochromes disinhibits the transcriptional activation of CLOCK:BMAL1 and NPAS2:BMAL1 target genes, resulting in increased levels of their transcripts in the SCN, liver, and retina [ 20 23 25 ] . We assayed the expression in the brain of three genes that are known targets of cryptochrome mediated transcriptional inhibition: albumin D-binding protein ( dbp [ 26 ] ), period (per)1 , and per2 [ 20 23 27 ] , in the middle of the daily light period.
Consistent with their central role in circadian rhythm generation, genetic inactivation of both cryptochromes ( cry1,2 -/-) results in circadian arrhythmicity in mice [ 22 23 ] . Given the widespread expression of the elements of the molecular clock in the brain (and elsewhere) and the large number of genes regulated by bHLH-PAS transcription factors (e.g.
Together, these unexpected results are compatible with a role for cryptochromes in the homeostatic regulation of sleep in addition to their role in generating circadian rhythms.
Thus, in the absence of cryptochromes , NREMS delta power varied as a function of the prior sleep-wake history.