Words similar to cryptochromes
Example sentences for: cryptochromes
How can you use “cryptochromes” in a sentence? Here are some example sentences to help you improve your vocabulary:
Together, these unexpected results are compatible with a role for cryptochromes in the homeostatic regulation of sleep in addition to their role in generating circadian rhythms.
[ 24 ] ), the role of cryptochromes may extend beyond circadian clock function.
Thus, in the absence of cryptochromes , NREMS delta power varied as a function of the prior sleep-wake history.
Consistent with their central role in circadian rhythm generation, genetic inactivation of both cryptochromes ( cry1,2 -/-) results in circadian arrhythmicity in mice [ 22 23 ] . Given the widespread expression of the elements of the molecular clock in the brain (and elsewhere) and the large number of genes regulated by bHLH-PAS transcription factors (e.g.
We assume that the effects on sleep we observed in cry1 , 2 -/-mice are a result of a lack of cryptochrome -dependent inhibition of the transcriptional activation provided by the bHLH-PAS heterodimers CLOCK:BMAL1 and NPAS2:BMAL1 [ 19 20 37 ] , although cryptochromes also play a role in stabilizing and nuclear sequestration of PER proteins [ 38 ] , and in photoreception [ 39 ] . Lack of cryptochromes results in increased mRNA levels of CLOCK/NPAS2:BMAL1 target genes, including the circadian genes per1 and per2 [ 20 23 ] . The expression of these two genes is viewed as a state variable of the molecular circadian clock or a marker of CLOCK/NPAS2:BMAL1-induced transcription, although at least per1 transcription can also be (rapidly) induced by light [ 40 41 ] , through a CREB-dependent signaling pathway [ 42 43 44 ] . The observation of high brain levels of per1,2 transcripts under baseline conditions in cry1,2 -/-mice raises the possibility that these or other CLOCK/NPAS2:BMAL1 target genes are involved in the homeostatic regulation of sleep.
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