Words similar to cryptochrome
Example sentences for: cryptochrome
How can you use “cryptochrome” in a sentence? Here are some example sentences to help you improve your vocabulary:
This cryptochrome mutation produced dramatic effects on the phase of both reporters in DD: The mean-phase values were estimated to occur more than 7 hours earlier for cry b antennae compared to the cry +appendages.
SUB1 was identified as a protein involved in the cryptochrome and phytochrome signaling pathways [ 50].
We assume that the effects on sleep we observed in cry1 , 2 -/-mice are a result of a lack of cryptochrome -dependent inhibition of the transcriptional activation provided by the bHLH-PAS heterodimers CLOCK:BMAL1 and NPAS2:BMAL1 [ 19 20 37 ] , although cryptochromes also play a role in stabilizing and nuclear sequestration of PER proteins [ 38 ] , and in photoreception [ 39 ] . Lack of cryptochromes results in increased mRNA levels of CLOCK/NPAS2:BMAL1 target genes, including the circadian genes per1 and per2 [ 20 23 ] . The expression of these two genes is viewed as a state variable of the molecular circadian clock or a marker of CLOCK/NPAS2:BMAL1-induced transcription, although at least per1 transcription can also be (rapidly) induced by light [ 40 41 ] , through a CREB-dependent signaling pathway [ 42 43 44 ] . The observation of high brain levels of per1,2 transcripts under baseline conditions in cry1,2 -/-mice raises the possibility that these or other CLOCK/NPAS2:BMAL1 target genes are involved in the homeostatic regulation of sleep.
Deletion of the cryptochromes disinhibits the transcriptional activation of CLOCK:BMAL1 and NPAS2:BMAL1 target genes, resulting in increased levels of their transcripts in the SCN, liver, and retina [ 20 23 25 ] . We assayed the expression in the brain of three genes that are known targets of cryptochrome mediated transcriptional inhibition: albumin D-binding protein ( dbp [ 26 ] ), period (per)1 , and per2 [ 20 23 27 ] , in the middle of the daily light period.
In the main, but by no means exclusively, the current analyses were applied to published data revolving round effects of the cryptochrome gene as it functions in Drosophila's circadian system [ 23 ] . The results of the present study show that procedures for detrending and normalizing the data clarify the presence versus absence of rhythmicity - which tend strongly to be associated with cry +functioning versus that putatively remaining in the cry b mutant - as well as permitting a more detailed understanding of the features accompanying a given molecular time-course.
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