Words similar to cryptochrome
Example sentences for: cryptochrome
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Deletion of the cycle gene in Drosophila produces flies that have an exaggerated homeostatic response to rest deprivation in addition to their lack of circadian rhythmicity [ 16 ] . In a striking parallel to our current results, flies with a mutation in the cryptochrome gene also exhibit increased rest time as well as a reduced compensatory response to rest deprivation (P.
This cryptochrome mutation produced dramatic effects on the phase of both reporters in DD: The mean-phase values were estimated to occur more than 7 hours earlier for cry b antennae compared to the cry +appendages.
Deletion of the cryptochromes disinhibits the transcriptional activation of CLOCK:BMAL1 and NPAS2:BMAL1 target genes, resulting in increased levels of their transcripts in the SCN, liver, and retina [ 20 23 25 ] . We assayed the expression in the brain of three genes that are known targets of cryptochrome mediated transcriptional inhibition: albumin D-binding protein ( dbp [ 26 ] ), period (per)1 , and per2 [ 20 23 27 ] , in the middle of the daily light period.
In the main, but by no means exclusively, the current analyses were applied to published data revolving round effects of the cryptochrome gene as it functions in Drosophila's circadian system [ 23 ] . The results of the present study show that procedures for detrending and normalizing the data clarify the presence versus absence of rhythmicity - which tend strongly to be associated with cry +functioning versus that putatively remaining in the cry b mutant - as well as permitting a more detailed understanding of the features accompanying a given molecular time-course.
We previously employed luc reporting to study the effects of a cryptochrome mutation ( cry b ), concentrating on clock gene expression in isolated antennal pairs from Drosophila [ 23 ] . Earlier studies established that cry encodes a 'deep-brain' element of the photoreceptive pathway to the circadian clock [ 24 25 26 ] . But our study suggested a different role for cry in the periphery, because antennal rhythmicity in mutant specimens was dramatically reduced in constant darkness [ 23 ] , an effect that is not consistent with the idea that the encoded protein (CRY) functions solely as a photoreceptor for the circadian system [ 24 25 ] .
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