Words similar to cryptochrome
Example sentences for: cryptochrome
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Previous studies of cryptochrome's chronobiological role in Drosophila emphasized that CRY may function as a deep brain photoreceptor involved in mediating resetting of the clock by light [ 26 ] . Support for this hypothesis came from the observation that locomotor-activity rhythms in cry b flies are unaffected in constant darkness and also maintain rhythmicity under constant light, a condition that causes behavioral arrhythmicity in the wild type [ 33 ] . While antennal rhythms of gene expression and of odor sensitivity in DD are significantly attenuated in cry b tissues ( [ 23 ] , unlike locomotor rhythmicity [ 21 ] ), it remained possible that such effects are due to an altered role of light on the developing clock.
In the main, but by no means exclusively, the current analyses were applied to published data revolving round effects of the cryptochrome gene as it functions in Drosophila's circadian system [ 23 ] . The results of the present study show that procedures for detrending and normalizing the data clarify the presence versus absence of rhythmicity - which tend strongly to be associated with cry +functioning versus that putatively remaining in the cry b mutant - as well as permitting a more detailed understanding of the features accompanying a given molecular time-course.
Deletion of the cycle gene in Drosophila produces flies that have an exaggerated homeostatic response to rest deprivation in addition to their lack of circadian rhythmicity [ 16 ] . In a striking parallel to our current results, flies with a mutation in the cryptochrome gene also exhibit increased rest time as well as a reduced compensatory response to rest deprivation (P.
Deletion of the cryptochromes disinhibits the transcriptional activation of CLOCK:BMAL1 and NPAS2:BMAL1 target genes, resulting in increased levels of their transcripts in the SCN, liver, and retina [ 20 23 25 ] . We assayed the expression in the brain of three genes that are known targets of cryptochrome mediated transcriptional inhibition: albumin D-binding protein ( dbp [ 26 ] ), period (per)1 , and per2 [ 20 23 27 ] , in the middle of the daily light period.
We previously employed luc reporting to study the effects of a cryptochrome mutation ( cry b ), concentrating on clock gene expression in isolated antennal pairs from Drosophila [ 23 ] . Earlier studies established that cry encodes a 'deep-brain' element of the photoreceptive pathway to the circadian clock [ 24 25 26 ] . But our study suggested a different role for cry in the periphery, because antennal rhythmicity in mutant specimens was dramatically reduced in constant darkness [ 23 ] , an effect that is not consistent with the idea that the encoded protein (CRY) functions solely as a photoreceptor for the circadian system [ 24 25 ] .
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