Words similar to cryptochrome
Example sentences for: cryptochrome
How can you use “cryptochrome” in a sentence? Here are some example sentences to help you improve your vocabulary:
In the main, but by no means exclusively, the current analyses were applied to published data revolving round effects of the cryptochrome gene as it functions in Drosophila's circadian system [ 23 ] . The results of the present study show that procedures for detrending and normalizing the data clarify the presence versus absence of rhythmicity - which tend strongly to be associated with cry +functioning versus that putatively remaining in the cry b mutant - as well as permitting a more detailed understanding of the features accompanying a given molecular time-course.
We assume that the effects on sleep we observed in cry1 , 2 -/-mice are a result of a lack of cryptochrome -dependent inhibition of the transcriptional activation provided by the bHLH-PAS heterodimers CLOCK:BMAL1 and NPAS2:BMAL1 [ 19 20 37 ] , although cryptochromes also play a role in stabilizing and nuclear sequestration of PER proteins [ 38 ] , and in photoreception [ 39 ] . Lack of cryptochromes results in increased mRNA levels of CLOCK/NPAS2:BMAL1 target genes, including the circadian genes per1 and per2 [ 20 23 ] . The expression of these two genes is viewed as a state variable of the molecular circadian clock or a marker of CLOCK/NPAS2:BMAL1-induced transcription, although at least per1 transcription can also be (rapidly) induced by light [ 40 41 ] , through a CREB-dependent signaling pathway [ 42 43 44 ] . The observation of high brain levels of per1,2 transcripts under baseline conditions in cry1,2 -/-mice raises the possibility that these or other CLOCK/NPAS2:BMAL1 target genes are involved in the homeostatic regulation of sleep.
Deletion of the cryptochromes disinhibits the transcriptional activation of CLOCK:BMAL1 and NPAS2:BMAL1 target genes, resulting in increased levels of their transcripts in the SCN, liver, and retina [ 20 23 25 ] . We assayed the expression in the brain of three genes that are known targets of cryptochrome mediated transcriptional inhibition: albumin D-binding protein ( dbp [ 26 ] ), period (per)1 , and per2 [ 20 23 27 ] , in the middle of the daily light period.
SUB1 was identified as a protein involved in the cryptochrome and phytochrome signaling pathways [ 50].
This cryptochrome mutation produced dramatic effects on the phase of both reporters in DD: The mean-phase values were estimated to occur more than 7 hours earlier for cry b antennae compared to the cry +appendages.
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