Words similar to cryptochrome
Example sentences for: cryptochrome
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Deletion of the cryptochromes disinhibits the transcriptional activation of CLOCK:BMAL1 and NPAS2:BMAL1 target genes, resulting in increased levels of their transcripts in the SCN, liver, and retina [ 20 23 25 ] . We assayed the expression in the brain of three genes that are known targets of cryptochrome mediated transcriptional inhibition: albumin D-binding protein ( dbp [ 26 ] ), period (per)1 , and per2 [ 20 23 27 ] , in the middle of the daily light period.
SUB1 was identified as a protein involved in the cryptochrome and phytochrome signaling pathways [ 50].
Deletion of the cycle gene in Drosophila produces flies that have an exaggerated homeostatic response to rest deprivation in addition to their lack of circadian rhythmicity [ 16 ] . In a striking parallel to our current results, flies with a mutation in the cryptochrome gene also exhibit increased rest time as well as a reduced compensatory response to rest deprivation (P.
Previous studies of cryptochrome's chronobiological role in Drosophila emphasized that CRY may function as a deep brain photoreceptor involved in mediating resetting of the clock by light [ 26 ] . Support for this hypothesis came from the observation that locomotor-activity rhythms in cry b flies are unaffected in constant darkness and also maintain rhythmicity under constant light, a condition that causes behavioral arrhythmicity in the wild type [ 33 ] . While antennal rhythms of gene expression and of odor sensitivity in DD are significantly attenuated in cry b tissues ( [ 23 ] , unlike locomotor rhythmicity [ 21 ] ), it remained possible that such effects are due to an altered role of light on the developing clock.
In the main, but by no means exclusively, the current analyses were applied to published data revolving round effects of the cryptochrome gene as it functions in Drosophila's circadian system [ 23 ] . The results of the present study show that procedures for detrending and normalizing the data clarify the presence versus absence of rhythmicity - which tend strongly to be associated with cry +functioning versus that putatively remaining in the cry b mutant - as well as permitting a more detailed understanding of the features accompanying a given molecular time-course.
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