Words similar to cryptochrome
Example sentences for: cryptochrome
How can you use “cryptochrome” in a sentence? Here are some example sentences to help you improve your vocabulary:
We previously employed luc reporting to study the effects of a cryptochrome mutation ( cry b ), concentrating on clock gene expression in isolated antennal pairs from Drosophila [ 23 ] . Earlier studies established that cry encodes a 'deep-brain' element of the photoreceptive pathway to the circadian clock [ 24 25 26 ] . But our study suggested a different role for cry in the periphery, because antennal rhythmicity in mutant specimens was dramatically reduced in constant darkness [ 23 ] , an effect that is not consistent with the idea that the encoded protein (CRY) functions solely as a photoreceptor for the circadian system [ 24 25 ] .
SUB1 was identified as a protein involved in the cryptochrome and phytochrome signaling pathways [ 50].
Previous studies of cryptochrome's chronobiological role in Drosophila emphasized that CRY may function as a deep brain photoreceptor involved in mediating resetting of the clock by light [ 26 ] . Support for this hypothesis came from the observation that locomotor-activity rhythms in cry b flies are unaffected in constant darkness and also maintain rhythmicity under constant light, a condition that causes behavioral arrhythmicity in the wild type [ 33 ] . While antennal rhythms of gene expression and of odor sensitivity in DD are significantly attenuated in cry b tissues ( [ 23 ] , unlike locomotor rhythmicity [ 21 ] ), it remained possible that such effects are due to an altered role of light on the developing clock.
This cryptochrome mutation produced dramatic effects on the phase of both reporters in DD: The mean-phase values were estimated to occur more than 7 hours earlier for cry b antennae compared to the cry +appendages.
Deletion of the cryptochromes disinhibits the transcriptional activation of CLOCK:BMAL1 and NPAS2:BMAL1 target genes, resulting in increased levels of their transcripts in the SCN, liver, and retina [ 20 23 25 ] . We assayed the expression in the brain of three genes that are known targets of cryptochrome mediated transcriptional inhibition: albumin D-binding protein ( dbp [ 26 ] ), period (per)1 , and per2 [ 20 23 27 ] , in the middle of the daily light period.
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