Example sentences for: cross-reactive

How can you use “cross-reactive” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Analyses by Soininen and colleagues have found that antibodies measured by standard ELISA in unimmunized children are highly cross-reactive between different serotypes, and that cross-reactive antibodies lack opsonophagocytic function and often appear in the absence of any documented exposure to a given capsular serotype.

  • Finally, we show that the variant induces broadly cross-reactive IgG antibodies, and that priming of animals with the variant protein results in higher titers of antigen-specific antibody upon subsequent immunization with the parent enzyme.

  • We confirmed the spatial distribution of NF-κB using a polyclonal goat anti-NF-κB p50 antibody (C-19) (Santa Cruz Biotechnology); this antibody has been shown to react with mouse p50 or p105; it is not cross-reactive with NF-κB p52, p65/RelA or p100.

  • This is especially relevant to the design of subunit vaccines for malaria and schistosomiasis where high titers of high affinity antibodies are usually the best defence against invading organisms [ 11 16 24 ] . Creating T cell epitopes in expressed proteins has been demonstrated here for Hartley strain guinea pigs, and for various inbred strains of mice [ 37 38 ] . Interestingly, the introduction of T cell epitopes from a hen-egg lysozyme or ovalbumin into mouse TNF-alpha also resulted in an increased cross-reactive antibody response in mice [ 38 ] . However, the protein construct was no longer cytotoxic for L929 cells, suggesting that the modified protein was not in the correct tertiary configuration.

  • As a result, age-specific antibody concentration data for any given serotype are “contaminated,” to a greater or lesser degree, by cross-reactive antibodies with other specificties.


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