Words similar to crk

Example sentences for: crk

How can you use “crk” in a sentence? Here are some example sentences to help you improve your vocabulary:

Tyrosine phosphorylation of the substrate domain leads to the recruitment of other downstream adaptors such as crk and nck, as well as other downstream effectors possessing SH2 domains, and signaling events attributed to this domain include activation of the JNK MAPK pathway and control of adhesion and migration of cells [ 6 10 16 38 44 ] . We constructed a chimera between a kinase that phosphorylates Cas in vivo and the substrate domain of Cas, in order to determine events regulated by this domain.
Thus, our data suggest that the tyrosine phosphorylated Cas SD acts as a decoy for endogenous Cas binding proteins and blocks signaling via crk to the activation of JNK, as well as transformation of cells by the oncogene v-crk.
We transfected v-crk alone or along with the chimera of the attenuated Src kinase domain fused to the C-terminal crk interacting region of the Cas substrate domain (Src*/Cas(3'SD), carrying the YDXP motifs) into Cos-7 cells and immunoprecipitated either the chimera or v-crk and assayed for interacting tyrosine phosphorylated proteins (Fig.
AA also performed JNK assays in transient transfections, analyzed the association of the chimeras with crk and drafted the manuscript.
KHK generated stable cell lines carrying the chimeras, and characterized these lines in soft agar transformation assays, activation of JNK, tyrosine phosphorylation of FAK, endogenous Cas and association of C3G with endogenous crk.