Words similar to cpbg

Example sentences for: cpbg

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For example construction of a "hybrid" ligand that combines the interactions of [ 3H]granisetron with those of d -tc, 5-HT or m CPBG could produce an antagonist with increased affinity due to the additional binding energy of these interactions and a greater specificity since it would utilize more structural features of the binding site.
This difference in binding site interactions of the antagonist d -tc and the agonists 5-HT and m CPBG could be the result of a slightly different positioning of d -tc in the binding site.
In contrast to 5-HT and m CPBG, however, lerisetron also interacts with Y152 as indicated by the 190 fold increase in K i on Y152A mutant receptors.
The 5-HT 3 R agonist m CPBG showed a similar profile for the changes in K i values resulting from mutations of the three tyrosines (Figure 4B).
R91, E106, F107, W183 and several residues adjacent to the M1 region have all been demonstrated to alter the action of 5-HT and/or m CPBG [ 20 21 25 26 ] . Within the crystal structure of the AChBP, homologous residues are located in the apparent binding site [ 24 ] . The effects of agonist on the 5-HT 3 R are mediated by their interaction with these binding site residues, resulting in stable receptor conformations, including the channel open state.