Words similar to cpbg
Example sentences for: cpbg
How can you use “cpbg” in a sentence? Here are some example sentences to help you improve your vocabulary:
[ 3H]granisetron was purchased from New England Nuclear, 5-HT from Spectrum, and m CPBG and d -tc from Research Biochemical International.
R91, E106, F107, W183 and several residues adjacent to the M1 region have all been demonstrated to alter the action of 5-HT and/or m CPBG [ 20 21 25 26 ] . Within the crystal structure of the AChBP, homologous residues are located in the apparent binding site [ 24 ] . The effects of agonist on the 5-HT 3 R are mediated by their interaction with these binding site residues, resulting in stable receptor conformations, including the channel open state.
This difference in binding site interactions of the antagonist d -tc and the agonists 5-HT and m CPBG could be the result of a slightly different positioning of d -tc in the binding site.
In contrast to 5-HT and m CPBG, however, lerisetron also interacts with Y152 as indicated by the 190 fold increase in K i on Y152A mutant receptors.
For example construction of a "hybrid" ligand that combines the interactions of [ 3H]granisetron with those of d -tc, 5-HT or m CPBG could produce an antagonist with increased affinity due to the additional binding energy of these interactions and a greater specificity since it would utilize more structural features of the binding site.
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