Example sentences for: cpa

How can you use “cpa” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Since CPAs are not required to belong to the AICPA in order to conduct public company audits, the most severe sanction would only serve to save the CPA some dues without any other practical effect.

  • For example, the membership soundly rejected the Institute's efforts to further stretch the CPA brand name and allow others to benefit from our profession's hard-earned reputation through the so-called "XYZ initiative."

  • (This document was written by David M. Walker, CPA, Comptroller General of the United States, based on a speech he gave to the American Institute of Certified Public Accountants' leadership conference in November 2002)

  • DEAB was first used to sensitize the mouse leukemic cell line L1210/CPA, which is resistant to 4-hydroperoxycyclophosphamide (4-HC) by virtue of its overexpression of ALDH1A1.

  • Treatment of L1210/CPA cells in vitro with 50 μM DEAB abolished the tumor cells' resistance to 4-HC [ 19 ] . DEAB also exhibited in vivo efficacy as a ALDH1A1 inhibitor, as demonstrated by the toxicity to the intestinal crypt cells in mice receiving co-injections of DEAB and cyclophosphamide [ 21 ] . More recently, DEAB has been used to demonstrate that overexpression of human ALDH1A1 in transfected cell lines is sufficient to cause cellular resistance to the oxazaphosphorines [ 22 ] and 4-HC [ 23 ] . DEAB has also been an effective reagent in fluorescent-activated cell sorting (FACS) techniques to isolate human hematopoietic stem cells based on the expression of ALDH1A1 activity [ 5 6 ] . In contrast to DEAB and DPAB, daidzin - a natural product isolated from Pueraria lobata (the Kudzu plant) - shows specificity for inhibiting ALDH2 at concentrations similar to that of DPAB used to inhibit ALDH1A1 [ 24 25 ] . An inhibitor specific for ALDH1A2 has not yet been reported.


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