Words similar to covalent
Example sentences for: covalent
How can you use “covalent” in a sentence? Here are some example sentences to help you improve your vocabulary:
For Corning slides, over-irradiation (150-450 mJ/cm 2) results in a decrease in the hybridization signal that may reflect excessive covalent attachment of oligonucleotides.
The well-known ubiquitin-dependent pathway involves the covalent attachment of ubiquitin to substrate proteins to form polyubiquitin chain, which then targets the marked substrates to proteasome for degradation [ 17 19 20 ] . The ubiquitin-independent pathway is not well defined, but involves targeting proteins other than ubiquitin.
Human Fhit protein, a member of the Fhit branch of the histidine triad superfamily of nucleotide-binding proteins, binds and hydrolyzes diadenosine polyphosphates such as ApppA and AppppA ( 1 ) into AMP plus ADP and ATP, respectively [ 8 9 10 ] . His96, which is responsible for covalent catalysis and more than 4× 10 6-fold of rate enhancement in ApppA hydrolysis [ 9 11 12 13 ] , is nonetheless dispensable for ApppA-binding and tumor suppression, suggesting that Fhit function in tumor suppression depends on formation of an E-S complex [ 2 12 ] . If Fhit-substrate complexes promote tumor suppression by stimulating a pro-apoptotic effector, then Fhit inhibitors that resemble natural substrates may promote Fhit function.
Whereas noncovalent interactions appear to be the predominant mechanism for oligonucleotide attachment, covalent linkage is likely to have an important supplementary role in UV-irradiated microarrays.
This is in agreement with the expectations from the covalent bond structure.
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