Example sentences for: costimulatory

How can you use “costimulatory” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The effects were determined to be a direct consequence of CD81 ligation on T cells, as anti-CD81 mAb pre-treatment of purified T cells, but not non-T cells, induced the costimulatory effects.

  • Several of the nonantigen-specific signals include costimulatory cell surface markers as well as the generation of a multitude of cytokines.

  • This effect of CD81 is not shared by other classical costimulatory molecules, such as CD28, which has been shown to induce the proliferation of both Th1 and Th2 cells (data not shown, and references [ 26 27 28 29 ] ).

  • Once IL-10 is produced it functions in an autoregulatory fashion to suppress proinflammatory cytokine mRNA expression and protein production [ 5 6 7 ] . In addition, IL-10 suppresses the expression of MHC class II molecules and costimulatory molecules such as intercellular adhesion molecule 1 and B7, leading to reduction in T-cell macrophage interactions [ 8 9 10 ] .

  • Therefore, to discriminate between the distinct genes induced by each ligand that contributes to the overall response initiated by antigenic stimulation, it is important to use cycloheximide to identify immediate/early genes regulated by the TCR and costimulatory receptors vs.


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