Words similar to costimulatory
Example sentences for: costimulatory
How can you use “costimulatory” in a sentence? Here are some example sentences to help you improve your vocabulary:
In addition, the genes activated by TCR, costimulatory receptors and IL-2 must be distinguished from those activated by IL-1, IL-6, IL-12, and TNF-α, as well as the genes regulated by the Toll-like receptors (TLR), all of which have been identified as mediators of lymphocyte activation events that were previously ascribed to LAF.
This caveat of the experimental system also implies that there could be considerable donor-to-donor variability in the effect of anti-CD81 mAb, as different donors could have different levels of endogenous CD81 costimulatory activity.
The effects were determined to be a direct consequence of CD81 ligation on T cells, as anti-CD81 mAb pre-treatment of purified T cells, but not non-T cells, induced the costimulatory effects.
It is well established that, besides the MHCII molecules, IFNg can induce susceptible tumors to upregulate the expression of MHC class I antigens [ 43 ] , tumor associated antigens [ 44 ] , costimulatory molecules [ 45 ] , and heat shock proteins [ 46 ] . In addition, IFNg may have antimetabolic and antiproliferative influence on certain types of tumor cells [ 47 ] . It has also been suggested that IFNg may cause responding tumor cells to secrete angiogenesis inhibitors [ 48 ] . As it is not known which of those IFNg effects are missing or restored by PMA in LS1034 cells, a thorough evaluation of the possible clinical implications of our in vitro findings is quite difficult.
Therefore, to discriminate between the distinct genes induced by each ligand that contributes to the overall response initiated by antigenic stimulation, it is important to use cycloheximide to identify immediate/early genes regulated by the TCR and costimulatory receptors vs.
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