Words similar to costimulatory
Example sentences for: costimulatory
How can you use “costimulatory” in a sentence? Here are some example sentences to help you improve your vocabulary:
The effects were determined to be a direct consequence of CD81 ligation on T cells, as anti-CD81 mAb pre-treatment of purified T cells, but not non-T cells, induced the costimulatory effects.
This caveat of the experimental system also implies that there could be considerable donor-to-donor variability in the effect of anti-CD81 mAb, as different donors could have different levels of endogenous CD81 costimulatory activity.
Interestingly, inhibition of Rho-p160ROCK has recently been shown to give similar lymphocyte morphology as inhibition of Rho with C3 [ 50 ] . Another interesting candidate may be p120 PKN, as recent studies have established that PKN phosphorylates cytoskeletal intermediate filaments [ 47 ] and is directly linked to the cytoskeletal network through associations with α-actinin [ 48 ] . Also, PKN may be involved in relating cytoplasmic signals to the nucleus, for in response to stress, nuclear translocation of PKN occurs [ 49 ] . This is particularly important in light of previous work demonstrating that inactivation of Rho in peripheral blood T lymphocytes inhibits costimulatory signals up-regulating IL-2 production [ 25 ] . Future experiments will focus on determining the relationship of Rho GTPases and the regulation of T cell morphology [ 25 51 52 ] .
Recently, Riley et al [ 43 ] and Diehn et al [ 44 ] described genes regulated by the TCR and the costimulatory receptors CD28, ICOS and CTLA-4, over a time course of 1-48 hours.
Once IL-10 is produced it functions in an autoregulatory fashion to suppress proinflammatory cytokine mRNA expression and protein production [ 5 6 7 ] . In addition, IL-10 suppresses the expression of MHC class II molecules and costimulatory molecules such as intercellular adhesion molecule 1 and B7, leading to reduction in T-cell macrophage interactions [ 8 9 10 ] .
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