Example sentences for: collagenases

How can you use “collagenases” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • We have shown in a quantitative manner that in all three cell types, MMP-1 and MMP-13 are inducible with IL-1, and that CDDO inhibits the expression of these collagenases, with optimal inhibition being observed after 24 hours of pretreatment with CDDO.

  • Of the MMPs, the collagenases [ 5, 6] and stromelysins [ 7] have been the best studied, and marked elevations in serum and synovial levels have been found in rheumatoid arthritis (RA) [ 8].

  • DMSO for 24 hours, before harvesting total RNA and determining expression of various MMP genes, including stromelysins 1 (MMP-3), 2 (MMP-10) and 3 (MMP-11), collagenases I (MMP-1) and IV (MMP-2) and meltrins α (ADAM-12) and β (ADAM-19).

  • Specifically, we have focused on MMP-1 and MMP-13, interstitial collagenases that have the unique ability to initiate cleavage of the triple helix comprising the stromal collagens types I, II, and III.

  • Furthermore, cycloheximide blocks mRNA expression of both collagenases [ 11, 16], indicating that expression of immediate early genes is required for MMP-1 and MMP-13 gene expression.


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