Words similar to colitis
Example sentences for: colitis
How can you use “colitis” in a sentence? Here are some example sentences to help you improve your vocabulary:
ECAMs support several forms of leukocyte adhesion including rolling, firm adhesion and extravasation [ 1 ] . Infiltration of tissues by leukocytes is a common hallmark of many chronic inflammatory states that include the inflammatory bowel diseases (IBD), ulcerative colitis (UC), and Crohn's disease (CD).
Several animal models and human studies support an absolute requirement for both MAdCAM-1 and a4b7 in the production of immune models of colitis.
Further support of this hypothesis comes from a more recent report by Binion's group showing that individuals afflicted with Crohn's colitis have an apparent inability to express iNOS in their intestinal microvascular endothelium [ 29].
Conversely, IL-10 gene-knockout mice develop a chronic colitis that is extremely similar to IBD [ 25 ] . IL-10 treatment can reduce inflammation in several models of colitis [ 26 27 28 29 30 ] and human IBD [ 31 32 33 34 35 ] . However, the clinical efficacy of systemically administered IL-10 for patients mild to moderately active Crohn's disease has not been as effective as hoped [ 33 34 35 ] . Furthermore the efficacy of IL-10 administration in mouse colitis models is contentious [ 36 ] .
In the setting of IBD, the expression of ECAMs like ICAM-1, VCAM-1, and MAdCAM-1 (mucosal addressin cell adhesion molecule-1) is observed in experimental models of colitis, [ 2 3 4 5 ] and also within the inflamed human colon in Crohn's disease and ulcerative colitis [ 6 7 ] .