Words similar to colitis
Example sentences for: colitis
How can you use “colitis” in a sentence? Here are some example sentences to help you improve your vocabulary:
IL-10, a cytokine produced by activated macrophages and Th2-type T cells, has crucial inhibitory effect against several Th-1 type immune responses, such as the antigen-presenting functions of monocytes and macrophages [ 52 53 ] . IL-10 may play an important role in preventing the induction of IBD, since animals deficient in IL-10 will develop colitis spontaneously, and low levels of IL-10 are positively correlated with recurrences of Crohn's disease [ 25 54 ] . However, unlike TNF-α based therapies, the administration of recombinant IL-10 (rIL-10) shows poor clinical efficacy.
In this group, intestinal A-GVHD was strongly favored, in the absence of other etiologies such as CMV colitis and NSAIDs [ 2 4 7 9 12 16 17 ] . CMV colitis cases were excluded morphologically based on the presence of CMV cytopathic effect or CMV immunohistochemistry.
This notion is well supported by several reports that show that antibodies directed against either MAdCAM-1, or its lymphocyte ligand, the α4β7 integrin will significantly attenuate several indices of gut damage in experimental models of colitis [ 9 47 ] .
Inflammatory bowel disease (IBD) is the term that encompasses chronic relapsing diseases characterized by inflammation of the bowel, specifically ulcerative colitis (UC) and Crohn disease (CD).
This may reflect the fact that TNF-α therapies for IBD are aimed at efficiently clearing TNF-α, while IL-10 therapies must increase IL-10 and recombinant IL-10 is likely too rapidly cleared from the circulation after in vivo administration to provide a uniform protection [ 55 ] . On the other hand, IL-10 gene transfer technology has been used with some success in models of colitis, however its effectiveness is also variable.
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