Words similar to cofactors
Example sentences for: cofactors
How can you use “cofactors” in a sentence? Here are some example sentences to help you improve your vocabulary:
The recent findings that members of the several different families of coactivators possess intrinsic histone acetyltransferase activity suggests that activated SHRs, and nuclear receptors in general, may also recruit these cofactors to remodel chromatin structure for better accessibility of the transcriptional machinery to DNA [ 5 6 ] .
In this regard, it is notable that some natural Group I introns have proven to be highly dependent upon protein cofactors, [ 35 ] and that Group I introns have been engineered whose tertiary structure and activity is dependent upon a peptide [ 36 ] . Such applications could also be melded with other innovations dependent upon the Group I self-splicing intron, such as the introduction of a trans-splicing intron that can potentially repair or modulate the expression of a given mRNA.
Variables identified as potential confounders by these bivariate analyses were included in multivariate models, as were the cofactors believed to be clinically relevant.
These cofactors interact with nuclear receptors in a ligand-dependent manner and enhance transcriptional activation via histone acetylation/methylation and recruitment of additional cofactors such as CBP/p300 [ 89 ] . CBP/p300 has been implicated in the functions of a large number of regulated transcription factors based primarily on physical interaction and the ability to potentiate transcription when overexpressed [ 90 ] . In the case of nuclear receptors, the interaction with CBP/p300 is ligand-dependent and relies on the conserved nuclear receptor functional domain, AF-2 (activation function 2).
ERβ might bind to yet more cofactors that contain variant NR boxes that resemble the β-box.
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