Example sentences for: cofactors

How can you use “cofactors” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The characterization of potentially altered interactions between hypophosphorylated RARα and its cofactors will provide unique insight into how post-translational modification of nuclear hormone receptors regulates repressor release, coactivator recruitment, histone acetylation, and transcriptional activation.

  • Variables identified as potential confounders by these bivariate analyses were included in multivariate models, as were the cofactors believed to be clinically relevant.

  • The fact that the binding of PEDF to cell surfaces decreases with heparin/HS depletion, implies that heparin/HS molecules might act as cofactors for PEDF-receptor interactions.

  • In this regard, it is notable that some natural Group I introns have proven to be highly dependent upon protein cofactors, [ 35 ] and that Group I introns have been engineered whose tertiary structure and activity is dependent upon a peptide [ 36 ] . Such applications could also be melded with other innovations dependent upon the Group I self-splicing intron, such as the introduction of a trans-splicing intron that can potentially repair or modulate the expression of a given mRNA.

  • Originally, these DPBB domains might have functioned as protein cofactors that stabilized a ribozyme RNA polymerase and eventually displaced the ribozyme as they acquired key residues required for protein-based polymerase activity.


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