Words similar to cofactors

Example sentences for: cofactors

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Variables identified as potential confounders by these bivariate analyses were included in multivariate models, as were the cofactors believed to be clinically relevant.
ERβ might bind to yet more cofactors that contain variant NR boxes that resemble the β-box.
ERα enhances AP-1 activity in response to estrogens, [ 28 29 ] but ERβ inhibits AP-1 activity in response to estrogens [ 29 30 31 ] . ERβ also completely suppresses ERα activity at the cyclin D1 promoter and even suppresses the activity of an ERα mutant that is selectively superactive at AP-1 sites and CREs [ 29 ] . Finally, ERβ shows a unique capacity to enhance AP-1 activity in response to selective estrogen receptor modulators (SERMs) such as raloxifene, tamoxifen and ICI 182,780/Faslodex (ICI) [ 30 31 32 ] . Together, these observations suggest that there are fundamental differences in the way that the ERs bind unspecified cofactors that modulate gene expression, and that some of these cofactors must play a role in differential ER activity at AP-1 sites.
acnAB, gapAC, gltA, icdA, pgk, rpiAB, tktAB ). Specifically, the gltA -, icdA -, and acnAB - in silico deletion strains were unable to produce one biosynthetic precursor (α-ketoglutarate, Table 1), and retained the capability to synthesize the remaining biosynthetic precursors and cofactors nearly equivalent to the wild-type.
Perhaps the ER isoforms enhance AP-1 activity by superficially similar mechanisms that involve different cofactors.