Words similar to co-activators
Example sentences for: co-activators
How can you use “co-activators” in a sentence? Here are some example sentences to help you improve your vocabulary:
Beta-catenin then accumulates in the nucleus where it interacts with its transcriptional co-activators, members of the Lymphoid Enhancer Factor/T Cell Factor (LEF/TCF) family of high mobility group DNA binding proteins to regulate gene expression [ 1 ] . Many downstream gene targets of the canonical Wnt/beta-catenin pathway have been identified http://www.stke.org.
The down-regulation is most apparent on cellular receptors that have intrinsic receptor tyrosine kinase (RTK) activity and signal transduction members that mediate RTK function; including the Ras-Raf-MEK pathway, and co-activators such as p300/CBP and SRC-1, which mediate gene expression related to hormone receptor genes.
It is difficult to interpret transcriptional profiling data alone, since dimerization, post-translational modifications, relative quantities of co-activators and co-repressors, and the formation of multiple transcriptional complexes binding to common promoter regions ultimately determines the binding activation potential of transcription factors.
Preliminary evidence suggests preferred ligands for PPAR activation are 18 C and 20 C FAs, as FAs shorter than 14 C or longer than 20 C will not fit correctly into the PPAR binding pocket and stabilize the AF-2 helix [ 17 ] . The net effect would be that PPAR co-activators are not recruited to relax nucleosomal DNA and allow transcription machinery to interact with various promoter elements.
However, our current knowledge of the molecular events involved in the recruitment of CBP/p300 and other transcriptional co-activators or co-repressors by Smads is still very limited.
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