Words similar to co-activator
Example sentences for: co-activator
How can you use “co-activator” in a sentence? Here are some example sentences to help you improve your vocabulary:
These genes belong to receptor, co-receptor, and co-activator pathways that are part of serine/threonine receptor tyrosine kinase, Ras/Raf/MEK/ERK (MAPK) cascade, which control proliferative and/or differentiation signals.
The fact that CCR4 has been characterized as a transcriptional co-activator has led to the speculation that nocturnin serves a similar function.
Note that the relevant transcriptional binding factor and/or co-activator for CRE (CREM and ACT) and for SRY in the adult (SRY) are testis-specific [ 37 38 ] . Future studies are necessary to determine if the transcriptional binding sites revealed by this study are functional in humans.
The functional significance of SNIP1 degradation is apparent, since SNIP1 is a constitutive interactor and functional repressor of the master transcription co-activator CBP/p300 [ 25 ] . In the BMP signaling pathways, SNIP1 is a potent inhibitor of Smad-responsive genes via inhibiting CBP/p300 (Fig.
In some cases, transcription factors may bind cooperatively to adjacent DNA sites via direct physical interaction [ 3 4 ] . In other cases, multiple transcription factors that bind independently may recruit a common co-activator [ 5 ] , or may act independently of one another to alter gene expression in response to distinct cellular cues [ 6 ] . Recent studies have also suggested that nearby transcription factors may collaboratively compete with nucleosomes, thus enhancing the binding of individual transcription factors [ 7 8 ] . Many experiments in yeast have shown that specific pairs of factors must be bound near each other for multifactorial regulation to occur [ 7 8 9 10 ] , and it is on these spatial constraints that we focus here.
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