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Example sentences for: cncss
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Under a simple mutational cold-spot hypothesis, CNCSs should occur randomly in non-coding DNA and the lengths of 'spacer intervals' between CNCSs should be exponentially distributed [ 46, 47].
Clustering of CNCSs has also been recently reported in the worm genome [ 47], and future research will determine if CNCS clustering is a general feature of non-coding conservation in metazoan genomes.
First, we demonstrate that the lengths of spacer intervals separating CNCSs are non-randomly distributed in the Drosophila genome, indicating a tendency for CNCSs to be clustered in non-coding DNA.
Second, we show that the spatial relationships of neighboring CNCSs are generally conserved as revealed by the strong correlation of spacer interval lengths in divergent species.
Most computational methods designed to identify CNCSs rely on the assumption that non-coding conservation implies functional constraint, rather than heterogeneity in mutation rates [ 45].
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