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Example sentences for: cncss

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Under a simple mutational cold-spot hypothesis, CNCSs should occur randomly in non-coding DNA and the lengths of 'spacer intervals' between CNCSs should be exponentially distributed [ 46, 47].
Clusters of CNCSs are readily apparent in VISTA plots of complex gene regions with known cis -regulatory function (Figures 2and 4).
Clustering of CNCSs and conservation of CNCS spacing are not expected under a mutational cold-spot hypothesis, and suggest that the spacer intervals between CNCSs, and therefore CNCSs themselves, are under functional constraint.
In addition, there is a strong tendency for known cis -regulatory elements to overlap clusters of CNCSs.
Most computational methods designed to identify CNCSs rely on the assumption that non-coding conservation implies functional constraint, rather than heterogeneity in mutation rates [ 45].